DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est4 and Ces1c

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_031980.2	Gene:	Ces1c / 13884	MGIID:	95420	Length:	554	Species:	Mus musculus

Alignment Length:	537	Identity:	153/537 - (28%)
Similarity:	228/537 - (42%)	Gaps:	105/537 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PVVQTTHGKVRG--ILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKC 72
            |||.||.|||.|  |.|:. :::....|.|:|:|.||||:|||..|...:||..:::.:.....|
Mouse    24 PVVDTTQGKVLGKYISLEG-FEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNATSYPPMC 87

  Fly    73 LQ----------VSTLTKEV---EGSEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFK-GGDSSR 121
            .|          :.:..||:   :.|||||||||  .........:||||:||||... ||.|..
Mouse    88 SQDAGWAKILSDMFSTEKEILPLKISEDCLYLNIYSPADLTKSSQLPVMVWIHGGGLVIGGASPY 152

  Fly   122 RAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPE 186
            .  |......||||.::|.:|||..|..|..|.  ..|||....|.:.||||::.|.|||.|:|:
Mouse   153 N--GLALSAHENVVVVTIQYRLGIWGLFSTGDE--HSPGNWAHLDQLAALRWVQDNIANFGGNPD 213

  Fly   187 RITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELN---RLPQMEYRLAKHLGYEGDNVD 248
            .:||||.|||.::|.:|:.||..:.||||||..:|..:..|   :..|....:...|....|...
Mouse   214 SVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVVINTNVGKKNIQAVNEIIATLSQCNDTSS 278

  Fly   249 SQVLEFL-LKADPALI-VSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNR 311
            :.:::.| .|.:..|: :|.       |...:|:.....|:....|.|     |.::......|.
Mouse   279 AAMVQCLRQKTESELLEISG-------KLVQYNISLSTMIDGVVLPKA-----PEEILAEKSFNT 331

  Fly   312 IPIILGANSGEGMSIFSFV------------KMNPS----WLKEFQCN---PERVLPWT----LR 353
            :|.|:|.|..|    |.::            |||..    .|:.|...   .|.::|..    ||
Mouse   332 VPYIVGFNKQE----FGWIIPMMLQNLLPEGKMNEETASLLLRRFHSELNISESMIPAVIEQYLR 392

  Fly   354 NRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQAPTYLY 418
            ...||.::.:|                       ::::|...|......|:...|......||:|
Mouse   393 GVDDPAKKSEL-----------------------ILDMFGDIFFGIPAVLLSRSLRDAGVSTYMY 434

  Fly   419 RFDFDSPDFNFYRIRFMG-KEQRGV--GHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQF 480
            .|.        ||..|:. |..:.|  .|.||:.::|..| ..|...|..|....:.::..:..|
Mouse   435 EFR--------YRPSFVSDKRPQTVEGDHGDEIFFVFGAP-LLKEGASEEETNLSKMVMKFWANF 490

  Fly   481 AATSDPNAPLTKSLVDW 497
            |...:||.   :.|..|
Mouse   491 ARNGNPNG---EGLPHW 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	153/537 (28%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	54/115 (47%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	152/536 (28%)
		Aes	<121..>234	CDD:223730	47/116 (41%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832574
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750