DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est4 and Ces1c

DIOPT Version :10

Sequence 1:NP_524266.1 Gene:alpha-Est4 / 40906 FlyBaseID:FBgn0015572 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_031980.2 Gene:Ces1c / 13884 MGIID:95420 Length:554 Species:Mus musculus


Alignment Length:537 Identity:153/537 - (28%)
Similarity:228/537 - (42%) Gaps:105/537 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 PVVQTTHGKVRG--ILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKC 72
            |||.||.|||.|  |.|:. :::....|.|:|:|.||||:|||..|...:||..:::.:.....|
Mouse    24 PVVDTTQGKVLGKYISLEG-FEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNATSYPPMC 87

  Fly    73 LQ----------VSTLTKEV---EGSEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFK-GGDSSR 121
            .|          :.:..||:   :.|||||||||  .........:||||:||||... ||.|..
Mouse    88 SQDAGWAKILSDMFSTEKEILPLKISEDCLYLNIYSPADLTKSSQLPVMVWIHGGGLVIGGASPY 152

  Fly   122 RAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPE 186
            .  |......||||.::|.:|||..|..|..|.  ..|||....|.:.||||::.|.|||.|:|:
Mouse   153 N--GLALSAHENVVVVTIQYRLGIWGLFSTGDE--HSPGNWAHLDQLAALRWVQDNIANFGGNPD 213

  Fly   187 RITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELN---RLPQMEYRLAKHLGYEGDNVD 248
            .:||||.|||.::|.:|:.||..:.||||||..:|..:..|   :..|....:...|....|...
Mouse   214 SVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVVINTNVGKKNIQAVNEIIATLSQCNDTSS 278

  Fly   249 SQVLEFL-LKADPALI-VSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNR 311
            :.:::.| .|.:..|: :|.       |...:|:.....|:....|.|     |.::......|.
Mouse   279 AAMVQCLRQKTESELLEISG-------KLVQYNISLSTMIDGVVLPKA-----PEEILAEKSFNT 331

  Fly   312 IPIILGANSGEGMSIFSFV------------KMNPS----WLKEFQCN---PERVLPWT----LR 353
            :|.|:|.|..|    |.::            |||..    .|:.|...   .|.::|..    ||
Mouse   332 VPYIVGFNKQE----FGWIIPMMLQNLLPEGKMNEETASLLLRRFHSELNISESMIPAVIEQYLR 392

  Fly   354 NRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQAPTYLY 418
            ...||.::.:|                       ::::|...|......|:...|......||:|
Mouse   393 GVDDPAKKSEL-----------------------ILDMFGDIFFGIPAVLLSRSLRDAGVSTYMY 434

  Fly   419 RFDFDSPDFNFYRIRFMG-KEQRGV--GHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQF 480
            .|.        ||..|:. |..:.|  .|.||:.::|..| ..|...|..|....:.::..:..|
Mouse   435 EFR--------YRPSFVSDKRPQTVEGDHGDEIFFVFGAP-LLKEGASEEETNLSKMVMKFWANF 490

  Fly   481 AATSDPNAPLTKSLVDW 497
            |...:||.   :.|..|
Mouse   491 ARNGNPNG---EGLPHW 504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est4NP_524266.1 alpha/beta hydrolases 8..529 CDD:473884 153/537 (28%)
Ces1cNP_031980.2 Esterase_lipase 25..525 CDD:238191 152/536 (28%)
Prevents secretion from ER. /evidence=ECO:0000255 551..554
Blue background indicates that the domain is not in the aligned region.

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