Protein Alignment alpha-Est4 and AADAC

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001077.2
• Gene: AADAC / 13
• HGNCID: 17
• Length: 399
• Species: Homo sapiens
• Alignment Length: 320
• Identity: 79/320 - (24%)
• Similarity: 113/320 - (35%)
• Gaps: 100/320 - (31%)

  Fly   106 MVYIHGG-------AFKGGDSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAG 163
            :.|||||       |..|.|...| |..|   :.:.|.:|..:||.|.....:.
Human   107 LFYIHGGGWCVGSAALSGYDLLSR-WTAD---RLDAVVVSTNYRLAPKYHFPIQ----------- 156

  Fly   164 LKDVILALRWI--RANAANFNGDPERITIFGHSSG----SMTVQLLLASPQSEGLFHRAILLAGF 222
            .:||..||||.  :...|.:..:||||.|.|.|:|    :...|.||..|..:      |.|...
Human   157 FEDVYNALRWFLRKKVLAKYGVNPERIGISGDSAGGNLAAAVTQQLLDDPDVK------IKLKIQ 215

  Fly   223 SMELNRLPQMEYRLAKHLGYEGDNVDSQVLEFLLKADPALIVS--ADFFT---PLEKRQGHNMPF 282
            |:....|..::..|..:  .|..|     ..||.|   :|:|.  :::||   .|||
Human   216 SLIYPALQPLDVDLPSY--QENSN-----FLFLSK---SLMVRFWSEYFTTDRSLEK-------- 262

  Fly   283 KPSIESYSTPNAVLLAEPIDLQRT------TWSNRIP--IILG---ANSGEGMSIFSFVKMNPSW 336
                       |:|..:.:.::.:      .||:.:|  .|.|   .|...|.|  ...|..|.:
Human   263 -----------AMLSRQHVPVESSHLFKFVNWSSLLPERFIKGHVYNNPNYGSS--ELAKKYPGF 314

  Fly   337 LKEFQC------NPERVLPWTLRNRC------DPG-----QRRQLGQALIHHFCE--AHG 377
            |.....      |..|.||.|....|      |.|     :.|..|..:.|:..|  .||
Human   315 LDVRAAPLLADDNKLRGLPLTYVITCQYDLLRDDGLMYVTRLRNTGVQVTHNHVEDGFHG 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	79/320 (25%)
AADAC	NP_001077.2	Abhydrolase_3	107..374	CDD:400284	77/318 (24%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	111..113		1/1 (100%)