Protein Alignment alpha-Est4 and AADACL3

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001096640.2
• Gene: AADACL3 / 126767
• HGNCID: 32037
• Length: 407
• Species: Homo sapiens
• Alignment Length: 168
• Identity: 35/168 - (20%)
• Similarity: 58/168 - (34%)
• Gaps: 57/168 - (33%)

  Fly   117 LGGSRTFYSTYCTSLASHGYVVAAVEHKDHSACWTYQLTEKNGELVEQPIKIKLIEKNE------ 175
            |.|...|....|..|.||...:...|| .||.              |:|     .|.||
Human    10 LSGGSPFACKVCGKLFSHKSNLTEHEH-FHSR--------------EKP-----FECNECGKAFS 54

  Fly   176 KNEFKIRNQQV--GKRVTECV---KALNVLEQLNLGTVPEKVLIGNDYNWAQFKNKLVMSSASVI 235
            :.::.|::|..  |:::.||.   ||.:..|.|   ...:|:..|......:...|..:..:::|
Human    55 QKQYVIKHQSTHSGEKLFECSDCGKAFSQKENL---LTHQKIHTGEKPFECKDCGKAFIQKSNLI 116

  Fly   236 GH-----------------SFGGATSLASSAYTTDFQK 256
            .|                 :|.|.::|      |:.:|
Human   117 RHQRTHTGEKPFICKECGKTFSGKSNL------TEHEK 148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	35/168 (21%)
AADACL3	NP_001096640.2	Abhydrolase_3	115..378	CDD:400284	7/40 (18%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	119..121		0/1 (0%)