Protein Alignment alpha-Est4 and Nlgn2

DIOPT Version :9

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_446444.1
• Gene: Nlgn2 / 117096
• RGDID: 621118
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 586
• Identity: 173/586 - (29%)
• Similarity: 257/586 - (43%)
• Gaps: 148/586 - (25%)

  Fly     7 EDAPVVQTTHGKVRGILLKSLYDE---QFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRD---- 64
            |..|||.|.:|:|||: .:.|.:|   ....|.|:|||.||||..||:.|.....|.|:|:
  Rat    39 ERFPVVNTAYGRVRGV-RRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTL 102

  Fly    65 ---CSKPLSKCLQVSTL----TKEVEG--------SEDCLYLNISVKTLNGDPM----------- 103
               |.:.|...|....|    |..:|.        ||||||||:.|.|.:| |:
  Rat   103 PPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDG-PLTKKRDEATLNP 166

  Fly   104 -----------PVMVYIHGGAFKGG------DSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSL 151
                       |||:::|||::..|      .|...|:|       ||:..::.:|||.|||||.
  Rat   167 PDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYG-------NVIVATLNYRLGVLGFLST 224

  Fly   152 NDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRA 216
            .|.  ...||.||.|.|.||||:..|.|:|.||||||||||..:|:..|.||:.|..|||||.:|
  Rat   225 GDQ--AAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKA 287

  Fly   217 ILLAG---FSMELNRLPQMEYR--LAKHLGYEGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQ 276
            |..:|   .|..:|..| ::|.  ||..:|.:.:: .::.:|.|.:.....:|..|.     :..
  Rat   288 IAQSGTAISSWSVNYQP-LKYTRLLAAKVGCDRED-STEAVECLRRKSSRELVDQDV-----QPA 345

  Fly   277 GHNMPFKPSIESYSTPNAVLLAEP-IDLQRTTWSNRIPIILGANSGEGM---------------S 325
            .:::.|.|.::....|:     :| |.:|:..:.| ..:::|.|.|||:               |
  Rat   346 RYHIAFGPVVDGDVVPD-----DPEILMQQGEFLN-YDMLIGVNQGEGLKFVEDSAESEDGVSAS 404

  Fly   326 IFSFVKMNPSWLKEFQCNPE--RVLPWTLR-------NRCDPGQRRQLGQALIHHFCEAHGHELT 381
            .|.|...|  ::......||  .||..|::       :| |.|:.|:
  Rat   405 AFDFTVSN--FVDNLYGYPEGKDVLRETIKFMYTDWADR-DNGEMRR------------------ 448

  Fly   382 VDHTNGLVELFT-HGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGK-EQRGVGH 444
                ..|:.||| |.:|.......:....| |:|.|.|.|        ::..:..|: |.....|
  Rat   449 ----KTLLALFTDHQWVAPAVATAKLHADY-QSPVYFYTF--------YHHCQAEGRPEWADAAH 500

  Fly   445 VDELGYIFKLP---AT--FKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTK--SLVDWKPVTR 502
            .|||.|:|.:|   ||  |..:.|:.:......::..:..||.|.|||.|:.:  ..:..|| .|
  Rat   501 GDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKP-NR 564

  Fly   503 F 503
            |
  Rat   565 F 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	173/586 (30%)
		Aes	<104..>219	CDD:223730	56/120 (47%)
Nlgn2	NP_446444.1	COesterase	42..601	CDD:395084	172/583 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336479
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840