DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est4 and ache

DIOPT Version :10

Sequence 1:NP_524266.1 Gene:alpha-Est4 / 40906 FlyBaseID:FBgn0015572 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_571921.1 Gene:ache / 114549 ZFINID:ZDB-GENE-010906-1 Length:634 Species:Danio rerio


Alignment Length:533 Identity:151/533 - (28%)
Similarity:239/533 - (44%) Gaps:80/533 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 VVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQ- 74
            ||.|..|:|:|..|.........||.|||||.||:|..|||.....|||:.:.:..:..:.|.| 
Zfish    30 VVATRLGRVQGTRLPVPDRSHVIAFLGIPYAEPPIGKRRFKRAEPKKPWNNVFEAKEFSNACYQF 94

  Fly    75 VSTLTKEVEG----------SEDCLYLNISV-KTLNGDPMPVMVYIHGGAFKGGDSSRRAWGPDY 128
            |.|......|          ||||||||:.| .|.....:.|||:|:||.|..|.||...:...|
Zfish    95 VDTSYPGFPGIEMWNPNRVMSEDCLYLNVWVPPTPRPQNLTVMVWIYGGGFYSGSSSLDVYDGRY 159

  Fly   129 F-MKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFG 192
            . ..|.||.:|:.:|:|..|||:||... :.|||.||.|..|||:|::.|...|.|:|:::||||
Zfish   160 LAYTEKVVVVSMNYRVGAFGFLALNGSS-DAPGNVGLYDQRLALQWVQENIHFFGGNPKQVTIFG 223

  Fly   193 HSSGSMTVQLLLASPQSEGLFHRAILLAGF------SMELNRLPQMEYRLAKHLGYEGDNVDSQV 251
            .|:|:.:|.:.:.||.|..||.||||.:|.      ::..:...:...:|.|.:|....| |:::
Zfish   224 ESAGAASVGMHVLSPDSRPLFTRAILQSGVPNTPWATVTFDEARRRTTKLGKLVGCTWGN-DTEL 287

  Fly   252 LEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIESY---STPNAVLLAEPIDLQRTTWSNRIP 313
            ::.|....|..::..: :..|.........|.|.::..   .||:|::.:......:        
Zfish   288 IDCLRNKHPQELIDQE-WQVLPWSSLFRFSFVPVVDGVFFPDTPDAMISSGNFKYTQ-------- 343

  Fly   314 IILGANSGEGMSIF------SFVKMNPSWL--KEFQCNPERVLP----------------WTLRN 354
            |:||.|..|| |.|      .|.|.|.|.:  ::|..:.:..:|                |...|
Zfish   344 ILLGVNQDEG-SYFLLYGAPGFSKDNESLISREDFLESVKMGVPHANDIGLEAVILQYTDWMDEN 407

  Fly   355 RCDPGQRRQ------LGQ----ALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLT 409
            .   ||:.:      :|.    ..:.||.:::.....:...:......|.|:.::......|..:
Zfish   408 N---GQKNRDAMDDIVGDQNVICPLQHFAKSYAQYAALHAQSSAAAPGTLGWGNSGPTGYNSGNS 469

  Fly   410 YGQAPTYLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLV 474
            :|  ..|||.||..:.:..:       .|..||.|..|:.::|.||...:|:.:..|....||::
Zfish   470 HG--AVYLYLFDHRASNLAW-------PEWMGVIHGYEIEFVFGLPLEKRLNYTAEEEKLSRRIM 525

  Fly   475 AMFVQFAATSDPN 487
            ..:..||.|.:||
Zfish   526 RYWANFARTGNPN 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est4NP_524266.1 alpha/beta hydrolases 8..529 CDD:473884 151/533 (28%)
acheNP_571921.1 COesterase 27..583 CDD:395084 151/533 (28%)
AChE_tetra 598..631 CDD:430146
Blue background indicates that the domain is not in the aligned region.

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