Protein Alignment alpha-Est4 and Ache

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: XP_036020624.1
• Gene: Ache / 11423
• MGIID: 87876
• Length: 616
• Species: Mus musculus
• Alignment Length: 547
• Identity: 162/547 - (29%)
• Similarity: 242/547 - (44%)
• Gaps: 86/547 - (15%)

  Fly    11 VVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQ- 74
            :|:...|::|||.||: ......||.|||:|.||:|:.||..|...:||.|:.|.:...:.|.|
Mouse    40 LVRVRGGQLRGIRLKA-PGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQY 103

  Fly    75 VSTLTKEVEG----------SEDCLYLNI-SVKTLNGDPMPVMVYIHGGAFKGGDSSRRAWGPDY 128
            |.||....||          ||||||||: :.......|.||:::|:||.|..|.:|...:...:
Mouse   104 VDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRF 168

  Fly   129 FMK-ENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFG 192
            ..: |..|.:|:.:|:|..|||:| ....|.|||.||.|..|||:|::.|.|.|.|||..:|:||
Mouse   169 LAQVEGAVLVSMNYRVGTFGFLAL-PGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFG 232

  Fly   193 HSSGSMTVQLLLASPQSEGLFHRAILLAG---------FSMELNRLPQMEYRLAK-HLGYEGDNV 247
            .|:|:.:|.:.:.|..|..|||||:|.:|         .:.|..|...:..||.. ..|..|.|
Mouse   233 ESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGN- 296

  Fly   248 DSQVLEFLLKADPALIVSADFFTPLEKRQGHNMP--------FKPSIES---YSTPNAVL-LAEP 300
            |::::. .|:..||        ..|...:.|.:|        |.|.::.   ..||.|:: ..:.
Mouse   297 DTELIA-CLRTRPA--------QDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDF 352

  Fly   301 IDLQRTTWSNRIPIILGANSGEGMSIF------SFVKMNPSWLKEFQCNPERVLPWTLRNRCDPG 359
            .|||         :::|....|| |.|      .|.|.|.|.:...|        :....|....
Mouse   353 QDLQ---------VLVGVVKDEG-SYFLVYGVPGFSKDNESLISRAQ--------FLAGVRIGVP 399

  Fly   360 QRRQL-GQALIHHFCE-AHGHELTVDHTNGLVELFT--HGFVHAMDRLIQSRLTYGQAPTYLYRF 420
            |...| .:|::.|:.: .|..:.|  |....:....  |..|..:.:| ..||....|..|.|.|
Mouse   400 QASDLAAEAVVLHYTDWLHPEDPT--HLRDAMSAVVGDHNVVCPVAQL-AGRLAAQGARVYAYIF 461

  Fly   421 DFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVAMFVQFAATSD 485
            :..:....:       ....||.|..|:.:||.||....|:.:..|....:||:..:..||.|.|
Mouse   462 EHRASTLTW-------PLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGD 519

  Fly   486 PNAPLTKSLVDWKPVTRFGKRMV-LNI 511
            ||.|.......|.|.|...::.| ||:
Mouse   520 PNDPRDSKSPQWPPYTTAAQQYVSLNL 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	162/547 (30%)
Ache	XP_036020624.1	COesterase	37..563	CDD:395084	162/547 (30%)