Protein Alignment alpha-Est4 and Ces1d

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_579829.3
• Gene: Ces1d / 113902
• RGDID: 70896
• Length: 565
• Species: Rattus norvegicus
• Alignment Length: 543
• Identity: 152/543 - (27%)
• Similarity: 231/543 - (42%)
• Gaps: 113/543 - (20%)

  Fly     5 YNEDAPVVQTTHGKVRG--ILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSK 67
            |....|||.|..|||.|  :.|:. :.:....|.|||:|.||||:|||..|...:||:.:::.:.
  Rat    19 YPSSPPVVNTVKGKVLGKYVNLEG-FAQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWNFVKNTTS 82

  Fly    68 PLSKCLQ----------VSTLTKE---VEGSEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKGG 117
            ....|.|          :.|..||   ::.||||||||:  .........:||||:||||....|
  Rat    83 YPPMCSQDAVGGQVLSELFTNRKENIPLQFSEDCLYLNVYTPADLTKNSRLPVMVWIHGGGLVVG 147

  Fly   118 DSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFN 182
            .:|... |......||||.::|.:|||..||.|..|...:  ||.|..|.:.||.|::.|.|||.
  Rat   148 GASTYD-GQVLSAHENVVVVTIQYRLGIWGFFSTGDEHSQ--GNWGHLDQVAALHWVQDNIANFG 209

  Fly   183 GDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQMEYRLAKHLG-YEG-- 244
            |:|..:||||.|:|..:|..|:.||.::.||||||..:|..:....:......:|..:. ..|
  Rat   210 GNPGSVTIFGESAGGFSVSALVLSPLAKNLFHRAISESGVVLTSALITTDSKPIANLIATLSGCK 274

  Fly   245 ------------DNVDSQVLEFLLKADPALIVSADFF-TPLEKRQGHNMPFKPSIESYSTPNAVL 296
                        ...:.::||..||.:   :...|.. .|.|     :.||.|::    ....||
  Rat   275 TTTSAVMVHCLRQKTEDELLETSLKLN---LFKLDLLGNPKE-----SYPFLPTV----IDGVVL 327

  Fly   297 LAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFV------------KMNPSWLKE--FQCNP--- 344
            ...|.::......|.:|.|:|.|..|    |.::            |::....|.  ::..|
  Rat   328 PKTPEEILTEKSFNTVPYIVGINKQE----FGWIIPTLMGYPLSEGKLDQKTAKSLLWKSYPTLK 388

  Fly   345 --ERVLPWTLR----NRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDRL 403
              |:::|....    ...||.:|:.|.|            :|..|...|:..:.          :
  Rat   389 ISEKMIPVVAEKYFGGTDDPAKRKDLFQ------------DLVADVMFGVPSVM----------V 431

  Fly   404 IQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMG--KEQRGVG-HVDELGYIFKLPATFKLDKSRP 465
            .:|....| |||::|.|:        ||..|:.  :.:..:| |.|||..:|..|  |..|.:..
  Rat   432 SRSHRDAG-APTFMYEFE--------YRPSFVSAMRPKTVIGDHGDELFSVFGSP--FLKDGASE 485

  Fly   466 EFTAIRRLVAMF-VQFAATSDPN 487
            |.|.:.::|..: ..||....||
  Rat   486 EETNLSKMVMKYWANFARNGSPN 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	151/540 (28%)
Ces1d	NP_579829.3	COesterase	22..545	CDD:395084	151/540 (28%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565