DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est4 and Ces1d

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_444430.2	Gene:	Ces1d / 104158	MGIID:	2148202	Length:	565	Species:	Mus musculus

Alignment Length:	548	Identity:	155/548 - (28%)
Similarity:	233/548 - (42%)	Gaps:	123/548 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YNEDAPVVQTTHGKVRG--ILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSK 67
            |....|||.|..|||.|  :.|:. :.:....|.|:|:|.||||:|||..|...:||..:::.:.
Mouse    19 YPSSPPVVNTVKGKVLGKYVNLEG-FTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTS 82

  Fly    68 PLSKCLQ----------VSTLTKE---VEGSEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKGG 117
            ....|.|          :.|..||   ::.|||||||||  .........:||||:||||....|
Mouse    83 YPPMCSQDAVGGQVLSELFTNRKENIPLQFSEDCLYLNIYTPADLTKNSRLPVMVWIHGGGLVVG 147

  Fly   118 DSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFN 182
            .:|... |......||||.::|.:|||..||.|..|....  ||.|..|.:.||||::.|.|||.
Mouse   148 GASTYD-GLALSAHENVVVVTIQYRLGIWGFFSTGDEHSR--GNWGHLDQVAALRWVQDNIANFG 209

  Fly   183 GDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSM-------ELNRLPQMEYRL---- 236
            |:|..:||||.|:|..:|.:|:.||.::.||||||..:|.|:       ::..:..:...|
Mouse   210 GNPGSVTIFGESAGGFSVSVLVLSPLAKNLFHRAISESGVSLTAALITTDVKPIAGLVATLSGCK 274

  Fly   237 ----AKHLGYEGDNVDSQVLEFLLKADPALIVSADFF-TPLEKRQGHNMPFKPS-IESYSTPNA- 294
                |..:.......:.::||..||.:   :...|.. .|.|     :.||.|: |:....|.|
Mouse   275 TTTSAVMVHCLRQKTEDELLETSLKLN---LFKLDLLGNPKE-----SYPFLPTVIDGVVLPKAP 331

  Fly   295 -VLLAEP----------IDLQRTTWSNRIPIILGANSGEG-----------MSIFSFVKMNPSWL 337
             .:|||.          |:.|...|.  ||.::|....||           ...:..:|::
Mouse   332 EEILAEKSFSTVPYIVGINKQEFGWI--IPTLMGYPLAEGKLDQKTANSLLWKSYPTLKIS---- 390

  Fly   338 KEFQCNPERVLPWT----LRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVH 398
                   |.::|..    |....|..:::.|.|            :|..|...|:..:.
Mouse   391 -------ENMIPVVAEKYLGGTDDLTKKKDLFQ------------DLMADVVFGVPSVI------ 430

  Fly   399 AMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMG--KEQRGVG-HVDELGYIFKLPATFKL 460
                :.:|....| |.||:|.|:        ||..|:.  :.:..:| |.||:..:|..|  |..
Mouse   431 ----VSRSHRDAG-ASTYMYEFE--------YRPSFVSAMRPKAVIGDHGDEIFSVFGSP--FLK 480

  Fly   461 DKSRPEFTAIRRLVAMF-VQFAATSDPN 487
            |.:..|.|.:.::|..| ..||...:||
Mouse   481 DGASEEETNLSKMVMKFWANFARNGNPN 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	154/546 (28%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	53/114 (46%)
Ces1d	NP_444430.2	COesterase	24..545	CDD:278561	154/543 (28%)
		Aes	<121..>239	CDD:223730	48/120 (40%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832642
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750