DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est4 and Ces2a

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_598721.1	Gene:	Ces2a / 102022	MGIID:	2142491	Length:	558	Species:	Mus musculus

Alignment Length:	579	Identity:	167/579 - (28%)
Similarity:	251/579 - (43%)	Gaps:	109/579 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 APVVQTTHGKVRGILL-----KSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKP 68
            :|:..|..|:|||..:     ||    ..:||.|||:|.||:|.|||..|.|.:||.|:||.:..
Mouse    31 SPIRNTHRGQVRGSFVHVKDTKS----GVHAFLGIPFAKPPVGLLRFAPPEDPEPWSGVRDGTSQ 91

  Fly    69 LSKCLQVSTLTKE-----------VEGSEDCLYLNISVKT--LNGDPMPVMVYIHGGAFKGG--- 117
            .:.|||...:..|           :..|||||||||...|  ..|..:||||:||||....|
Mouse    92 PAMCLQPDIMNLEDAKEMNLILPPISMSEDCLYLNIYTPTHAQEGSNLPVMVWIHGGGLVVGSAS 156

  Fly   118 --DSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAAN 180
              |.|:.|      ..|.:|.::|.:|||.|||.|..|.  ...||.|..|.:.||||::.|.|.
Mouse   157 MNDVSKLA------ATEEIVIVAIQYRLGVLGFFSTGDQ--HARGNWGYLDQVAALRWVQKNIAY 213

  Fly   181 FNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLP-------QMEYRLAK 238
            |.|:.:|:||||.|:|..:|...:.||.|:||||.||:.:|.::    ||       ::.|:...
Mouse   214 FGGNRDRVTIFGVSAGGTSVSSHILSPMSKGLFHGAIMQSGVAL----LPDLISDTSEVVYKTVA 274

  Fly   239 HL-GYEGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFK--PSIESYSTPNAVLLAEP 300
            :| |.|.  .||:.|...|:|.....:.|           .|..||  |::    .....|...|
Mouse   275 NLSGCEA--TDSEALIHCLRAKSKQEILA-----------INQVFKMIPAV----VDGEFLPKHP 322

  Fly   301 IDLQRTTWSNRIPIILGANSGE-GMSIFSFVKMNPSWLKEFQCNPERVLPWTLRNRCDPGQRRQL 364
            .:|..:...:.:|.|:|.|:.| |..:..|:.:: ..:|..   ....||..|:|   ...|..|
Mouse   323 QELLTSMDFHPVPSIIGVNTDECGWGVPMFMGLD-HIIKNI---TRETLPAVLKN---TAARMML 380

  Fly   365 GQALIHHFCEAHGHELTVDHTNGLVELFTH---GFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPD 426
            .....|...|.:..:.....|  |...|..   .|:..:..|..:.....|||.|.|.|...|
Mouse   381 PPECSHLLVEEYMGDTEDPET--LQAQFREMLGDFMFVIPALQVAHFQRSQAPVYFYEFQHLS-- 441

  Fly   427 FNFYRIRFMGKEQRGVGHVDELGYIF-KLPATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPL 490
             :|  |:.:........|.|::.::| .......||.:..|....|.::..:..||...:||
Mouse   442 -SF--IKHVRPSHVKADHGDDVAFVFGSYLWDMNLDLTEEEELLKRMMMKYWANFARNGNPN--- 500

  Fly   491 TKSLVDWKPVTRFGKRMVLNISEE-LKFIPQP------EMPKLKFF-----DRLYEMAG 537
            ::.|..|.         ||:..|: |:...||      :..:|:|:     .::.|:.|
Mouse   501 SEGLPSWP---------VLDHDEQYLQLDTQPAVGRALKARRLQFWTKTLPQKIQELKG 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	164/564 (29%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	52/119 (44%)
Ces2a	NP_598721.1	COesterase	30..537	CDD:278561	164/564 (29%)
Ces2a	NP_598721.1	Aes	<127..>230	CDD:223730	44/110 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832757
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740