DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est4 and bche

DIOPT Version :10

Sequence 1:NP_524266.1 Gene:alpha-Est4 / 40906 FlyBaseID:FBgn0015572 Length:541 Species:Drosophila melanogaster
Sequence 2:XP_002931610.1 Gene:bche / 100495889 XenbaseID:XB-GENE-980117 Length:602 Species:Xenopus tropicalis


Alignment Length:579 Identity:162/579 - (27%)
Similarity:256/579 - (44%) Gaps:102/579 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 NEDAPVVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLS 70
            |.:..:|.|.:|||.|:.: |::.....||.|||||.||:|.||||:|...|||..|.:.|:..:
 Frog    27 NGETDIVDTKYGKVTGVQI-SVFSGIITAFLGIPYAEPPIGDLRFKKPVPHKPWSEIWNASQYGN 90

  Fly    71 KCLQ-VSTLTKEVEG----------SEDCLYLNISVKTLNGDPMP----VMVYIHGGAFKGGDSS 120
            .|.| |..:.....|          |||||||||.:.|    |.|    |||:|:||:|:.|.||
 Frog    91 SCYQTVDQIFPGFSGAEMWNPNTQLSEDCLYLNIWIPT----PKPRNASVMVWIYGGSFETGTSS 151

  Fly   121 RRAWGPDYFMK-ENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGD 184
            ...:...:..: |.|:.:|:.:|||.||||:....: |.|||.||.|..|||:|:..|.|.|.|:
 Frog   152 LDLYDGKFLARTERVIVVSMNYRLGALGFLAFPGNN-EAPGNVGLFDQRLALQWVYENIAAFGGN 215

  Fly   185 PERITIFGHSSGSMTVQLLLASPQSEGLFHRAIL----------------LAGFSMELNRLPQME 233
            |:.|||||.|:|..:|...:.||:|.|.|.|||:                .:..::.|..|....
 Frog   216 PKSITIFGESAGGASVSYHMLSPKSHGFFTRAIMQSATANAPWAVITKAEASNRALTLANLLNCF 280

  Fly   234 YRLAKHLGYEGDNVDSQVLEFLLKADPALI----VSADFFTPLEKRQGHNMPFKPSIESYSTPNA 294
            ||           .:::::..|....|..|    ||.     |..|....:.|.|:::     ..
 Frog   281 YR-----------NETEIIACLRNKSPEEIFEKAVSV-----LPHRSVIEVNFPPTVD-----GD 324

  Fly   295 VLLAEP-IDLQRTTWSNRIPIILGANSGEGMSIF------SFVKMNPSWLKEFQCNPERVLPWTL 352
            .|:..| |.:|......:..|:.|.|..|| |.|      .|.|.:.|::...|.:....|.:  
 Frog   325 FLIEMPEILMQLGQLKKKTQILTGVNKDEG-SYFLVYGLPGFSKDHESFINRTQFHKSVKLAF-- 386

  Fly   353 RNRCDPGQRRQLGQALIHHFCE-------AHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTY 410
                 |........:::.|:..       :|..: .:|...|     .:.|:..:....:.....
 Frog   387 -----PKATELAIDSVLFHYTNWEDEQNPSHNRD-AMDDIVG-----DYNFICPLLEFTKWNSEL 440

  Fly   411 GQAPTYLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLVA 475
            |. ..|||.|...|.     ::.:.|  ..||.|..|:.::|.:|...:|:.::.|.|..|.|:.
 Frog   441 GN-NAYLYYFHHRSS-----KLTWPG--WMGVMHGYEIEFVFGIPMYRRLNYTKAEETLSRTLMR 497

  Fly   476 MFVQFAATSDPNAPLTKSLVDWKPVTRFGKRMVLNI-SEELKFIPQPEMPKLKFFDRLY 533
            .:..||.|.:||.  .:|..:..||....::..|.: :|:.|...:....:.:|::..|
 Frog   498 YWANFAKTGNPNG--AQSSENRWPVFTLDEQHYLMLGTEDSKTNRKMRAKQCRFWNNFY 554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est4NP_524266.1 alpha/beta hydrolases 8..529 CDD:473884 159/571 (28%)
bcheXP_002931610.1 COesterase 32..550 CDD:395084 159/568 (28%)
AChE_tetra 565..599 CDD:430146
Blue background indicates that the domain is not in the aligned region.

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