DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est4 and ces3.5

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_031756661.1	Gene:	ces3.5 / 100493652	XenbaseID:	XB-GENE-6467133	Length:	557	Species:	Xenopus tropicalis

Alignment Length:	596	Identity:	168/596 - (28%)
Similarity:	245/596 - (41%)	Gaps:	156/596 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EDA-PVVQTTHGK-------VRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIR 63
            ||| |.:.|.:|:       |||.      |...:||.|:|:|..|:|.|||.:|...:||..||
Frog    23 EDARPRLTTKYGQLLGKTVNVRGA------DRHVHAFMGVPFAKAPVGHLRFADPQPPEPWSSIR 81

  Fly    64 DCSKPLSKCLQ--VSTLTK--EVE-----GSEDCLYLNI--SVKTLNGDPMPVMVYIHGGAFKGG 117
            :.|.....|||  :..|.|  ::|     .||||||||:  .........:||||:||||....|
Frog    82 EASVIPPMCLQHGMEQLIKLFKIEFVLPASSEDCLYLNVFTPADRKENSKLPVMVFIHGGGLLMG 146

  Fly   118 DSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFN 182
            .:|... |......||||.:||.:|||.|||.|..|.  |..||.|..|.:.||:|::.|...|.
Frog   147 LASMFD-GSALSGYENVVVVSIQYRLGILGFFSTGDK--EAQGNFGFLDQVAALKWVQENIKEFG 208

  Fly   183 GDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAGFSMELNRLPQMEYRLAKHLGYEGDNV 247
            ||||.:||||.|:|.::|...:.||.|:|||||||..:|.::    ||.:              |
Frog   209 GDPESVTIFGQSAGGLSVSTHVLSPLSKGLFHRAIAESGVAL----LPGL--------------V 255

  Fly   248 DSQVLEFLLKADPALIVSADFFTPL-----EKRQGHNMPFKPSIESYSTP---NAVLLAEPI-DL 303
            .|:..|.|...|....:|......|     :|.:...|....:::..:.|   :.|.|.:|: ::
Frog   256 VSKTEEVLFVRDLVASLSGCNIKGLVDCLKKKTEEEIMAISATMQFTALPACVDGVFLPKPVEEI 320

  Fly   304 QRTTWSNRIPIILGANSG----------------EGMS-------------IFSFVKMNPSWLKE 339
            .....|||:|.::|.|:.                |||.             :.|...:.|..:||
Frog   321 LANKESNRVPFLIGFNNNEFGWMLPMALNISGFREGMGRKEVQSVLSALPLLHSVSSLVPLLMKE 385

  Fly   340 F--QCNPERVLPWTLRNRCDPGQRRQLGQALIHHFCEAHGHELTVDHTNGLVELFTHGFVHAMDR 402
            :  ..|.:.    .:||:                |.|.:|..|               ||....|
Frog   386 YFGDTNDQT----EIRNK----------------FLELNGDIL---------------FVIPALR 415

  Fly   403 LIQSRLTYGQAPTYLYRFD-----FDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLP-----AT 457
            ..|.....| .|.|||.|.     :|:...:|.:          ..|.|||.::...|     |.
Frog   416 TAQYHRDSG-LPVYLYEFQHRPSLYDNSKDDFVK----------ADHGDELYFVLGGPFLNGDAI 469

  Fly   458 FKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLVDWKPVTRFGKRMVLNISEE-------- 514
            |:.|.:..|....:.::..:..||...|||.|   .||:|.........:.:|:.::
Frog   470 FQSDGTDEEKNLSKTMMKYWANFARNGDPNGP---GLVEWPAYDEDKDYLEINLKQKSSWRLKEG 531

  Fly   515 -LKF--IPQPE 522
             |||  :..||
Frog   532 RLKFWTVTLPE 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	168/596 (28%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	56/114 (49%)
ces3.5	XP_031756661.1	COesterase	27..536	CDD:395084	162/584 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010