DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est4 and ache

DIOPT Version :9

Sequence 1:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_002940088.1	Gene:	ache / 100490673	XenbaseID:	XB-GENE-923160	Length:	600	Species:	Xenopus tropicalis

Alignment Length:	557	Identity:	166/557 - (29%)
Similarity:	238/557 - (42%)	Gaps:	112/557 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VVQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLSKCLQ- 74
            :|.|..||||| |.:.:......||.|||:|.||:..:||:.....|||..:.|.:...:.|.|
Frog    30 LVSTRSGKVRG-LRQPVLSTHVSAFLGIPFAEPPVDKMRFRRSEPKKPWTDVWDATAYPNACYQY 93

  Fly    75 VSTLTKEVEG----------SEDCLYLNISVKTLNGDPMPVMVYIHGGAFKGGDSSRRAWGPDYF 129
            ..||.....|          |||||||||.|.........|||:|:||.|..|.||...:...|.
Frog    94 FDTLYPGFPGMEMWNPNRPMSEDCLYLNIWVPHPRPSNATVMVWIYGGGFYSGSSSLDVYDGRYL 158

  Fly   130 M-KENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGH 193
            . .|||:.:|:.:|:|..|||:|....::.|||.||.|..|||:|::.|.|.|.|||..:||||.
Frog   159 CHAENVIVVSMNYRVGAFGFLTLTPGSVDAPGNVGLFDQRLALQWVQDNIAFFGGDPRTVTIFGE 223

  Fly   194 SSGSMTVQLLLASPQSEGLFHRAILLAG---------FSMELNRLPQMEYRLAKHLGYEGDNVDS 249
            |:|:::|.:.:.||.|..||.:|.|.:|         ...|..|..::   |.|.|.....| |:
Frog   224 SAGAVSVGMHVLSPGSHHLFSKAALQSGSPNTPWATITPQEARRRTEL---LGKFLDCRMGN-DT 284

  Fly   250 QVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIESYS---TPNAVLLAEPID-LQRTTWSN 310
            ::|..|....|..::..:|..         :| .||:..::   .|:|....||.: |.......
Frog   285 ELLNCLRVKQPQELIDHEFSV---------LP-APSVFRFAFVPVPDADFFPEPPEILMNMGRFK 339

  Fly   311 RIPIILGANSGEGMSIF------SFVKMNPSWL--KEFQCNPERVLPWTLRNRCDPGQRRQLGQA 367
            ..|:|:|.|..|| |.|      .|.|.|.|.:  :||                       ||
Frog   340 PCPLIMGVNQNEG-SYFLLYGAPGFSKNNESLITREEF-----------------------LG-- 378

  Fly   368 LIHHFCEAHGHELTVDHTN-----GLVELFT-----HGFV---HAMDRLIQSR-----LTY---- 410
                     |.:::|...|     .:|..:|     |..|   .|||:|:...     |||
Frog   379 ---------GVKMSVPQANDIALEAVVMQYTDWADEHAGVKNREAMDQLVGDHNVICPLTYFAGK 434

  Fly   411 -GQAPTYLYRFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTAIRRLV 474
             .:....:|.:.||....|....::|     ||.|..|:.::|.||....|:.:..|....||::
Frog   435 VAETGNRVYTYFFDHRASNLAWPQWM-----GVPHGYEIEFVFGLPLDANLNYTPQEEALSRRMM 494

  Fly   475 AMFVQFAATSDPNAPLTKSLVDWKPVTRFGKR-MVLN 510
            ..:..||.|.|||.........|...|...:| |.||
Frog   495 RYWANFARTGDPNEGNDAHQPRWPLYTASEQRYMALN 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	166/557 (30%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	50/115 (43%)
ache	XP_002940088.1	COesterase	31..549	CDD:395084	166/556 (30%)
ache	XP_002940088.1	AChE_tetra	564..597	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910