Protein Alignment alpha-Est4 and nlgn4x

DIOPT Version :10

• Sequence 1: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: XP_017946613.1
• Gene: nlgn4x / 100329189
• XenbaseID: XB-GENE-6036018
• Length: 833
• Species: Xenopus tropicalis
• Alignment Length: 616
• Identity: 172/616 - (27%)
• Similarity: 253/616 - (41%)
• Gaps: 142/616 - (23%)

  Fly     4 DYNEDAPVVQTTHGKVRG----ILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRD 64
            |.....|:|.|.:||:||    :.::.|...:.|.  |:|||.||.|..||:.|.....|.||::
 Frog    40 DCQAQHPIVPTNYGKIRGTRTPLPIEILGPVEQYL--GVPYASPPTGERRFQPPEPPSSWTGIKN 102

  Fly    65 CSKPLSKCLQ-------------------VSTLTKEVEG-SEDCLYLNISVKTLNG--------- 100
            .::....|.|                   :.|:...|:. :||||||||.|.|.:|
 Frog   103 ATQFAPVCPQFLDERSLLNDMLPIWFTANLDTVVSYVQDQNEDCLYLNIYVPTEDGATTKKQADD 167

  Fly   101 -------------DP---MPVMVYIHGGAFKGG-----DSSRRAWGPDYFMKENVVYISIGHRLG 144
                         ||   .|||||||||::..|     |.|..|      ...||:.|::.:|||
 Frog   168 IANNDRGEDEDIHDPNNKKPVMVYIHGGSYMEGTGNMIDGSILA------SHGNVIVITVNYRLG 226

  Fly   145 PLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQS 209
            .|||||..|.  ...||.||.|.|.|||||..|...|.|||:|:||||..:|:..|.||..|..|
 Frog   227 VLGFLSTGDQ--AAKGNYGLLDQIQALRWIEENIGAFGGDPKRVTIFGSGAGASCVSLLTLSHYS 289

  Fly   210 EGLFHRAILLAGFSME---LNRLPQMEYRLAKHLGYEGDNVDSQVLEFL-----LKADPALIVSA 266
            ||||.:||:.:|.::.   :|      |:.||:.....|.|...:|:.:     |:......:..
 Frog   290 EGLFQKAIIQSGTALSSWAVN------YQPAKYTRILADKVGCDMLDTIDLVECLRDKNYKELIQ 348

  Fly   267 DFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVK 331
            ...||..    :::.|.|.|:....|:     :|..|..........|:||.|.|||:.....:.
 Frog   349 QSITPAT----YHIAFGPVIDGDVIPD-----DPQILMEQGEFLNYDIMLGVNQGEGLKFVDGMV 404

  Fly   332 MNPSW--LKEFQCNPERVLPWTLRNRCD-----PGQRRQLGQALIHHFCEAHGHELTVDHTNGLV 389
            .|...  |.:|.        :::.|..|     |..:..|.:.:...:.:....|........||
 Frog   405 DNEDGVSLSDFD--------FSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLV 461

  Fly   390 ELFT-HGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRF-MGKEQRGVGHVDELGYIF 452
            .||| |.:|............|| :|||.|.|        ::..:. |........|.||:.|:|
 Frog   462 ALFTDHQWVAPAVATADLHARYG-SPTYFYAF--------YHHCQSEMKPTWADSAHGDEVPYVF 517

  Fly   453 KLP-----ATFKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTK--SLVDWKPVTRFGKRMVLN 510
            .:|     ..|..:.|:.:......::..:..||.|.|||.|:.:  ..:..|| .||
 Frog   518 GIPMIGPTELFNCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKP-NRF------- 574

  Fly   511 ISEEL---KFIPQPEMPKLKFFDRLYEMAGV 538
              ||:   |:.|:         |:||...|:
 Frog   575 --EEVAWSKYDPK---------DQLYLHIGL 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	167/601 (28%)
nlgn4x	XP_017946613.1	COesterase	46..610	CDD:395084	171/610 (28%)