DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est5 and Ces2f

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001073334.2	Gene:	Ces2f / 71903	MGIID:	1919153	Length:	561	Species:	Mus musculus

Alignment Length:	530	Identity:	150/530 - (28%)
Similarity:	234/530 - (44%)	Gaps:	92/530 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GQIKGVKRLSLYD--DPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQRGLLT 80
            ||::| |.:.|.|  ....:|..|||||||:|.|||..|...:|||||.|.|.......|...:.
Mouse    41 GQVRG-KFVHLTDIKAGAHNFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSQPAMCLQNDDIV 104

  Fly    81 REIEG-------------GEDCLYLNVYSKQLKSE-KPLPVMVYIYGGAFTVGEATRELY-GPDY 130
             .:||             .|||||||:|:.....| ..|||||:::||....|.|:  :| |...
Mouse   105 -NLEGLKIIKMILPPFSMSEDCLYLNIYTPAHAQEGSNLPVMVWLHGGGLVAGMAS--MYDGSVL 166

  Fly   131 FMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGE 195
            ..|:|||:|...||:...||.|..|...:  ||.|..||..||.||:|.|:||.|:..::|:||:
Mouse   167 AATEDVVVVVTQYRLGIPGFYSTGDEQAR--GNWGFLDQTAALHWVQQNIANFGGNPDSVTLFGQ 229

  Fly   196 SAGGCSTHFMMCTEQTRGLFHKAIPMSGT--VHNYWANNPAEDFAFRLAQQNGFTGENDDAKVLE 258
            ||||.|..|.:.:..::||||:||..||.  :.....::|...|. ::|..:|....|.:| ::.
Mouse   230 SAGGTSVSFHVLSPVSQGLFHRAIMESGVALLPTIIPDSPEMIFT-KVANLSGCETSNSEA-LVR 292

  Fly   259 YLQGVPARDLVNHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVMLGG 323
            .|:|....:::          .....|.|.|.|.    :...:|:.|.::...|..:..|.::|.
Mouse   293 CLRGKSEAEIL----------AMSKAFRFMPAVV----DGKFLPRHPKKLLASADFHPVPSIIGV 343

  Fly   324 TSFEGLFMYPAV-----------SANLKALDSLSQD----PTRLVPVDVRTVSSEKEN---LEYS 370
            .:.|..::.|.:           ..||||:..::.:    |:....:.:.....:.|:   |:..
Mouse   344 NNDEYGWIIPKIFKFSQTIRKINRNNLKAIMKITTEQMMLPSECGDLLIEEYLRDTEDPWTLQMQ 408

  Fly   371 QRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFNRTFNARLTYAKAPTYYYRFDFDSPNFNFYR 435
            .|.|...|....|:.::                      ||...:.||.|:|.|...|....::|
Mouse   409 FREMIGDFLIIIPALQV----------------------ARFQRSHAPVYFYEFQHRSSLLKYFR 451

  Fly   436 AKFCGDKIKTGVAHADDLSYLFRNAGSW--KLDKTSAEYRTIERMIGIWTAFAATSNPNCPEIGH 498
            ..    .:|..  |.|:| ||...:..|  |...|:.|.....:|:..|..||...|||..::.:
Mouse   452 PW----HVKAD--HGDEL-YLIFGSFFWGLKFSFTAEEKLLSRKMMKYWANFARYGNPNSEDLPY 509

  Fly   499 LEWKPSTKND 508
              |..|.::|
Mouse   510 --WPASNQDD 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	150/530 (28%)
Ces2f	NP_001073334.2	COesterase	32..540	CDD:395084	150/530 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832772
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.640