DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and TG

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_003226.4	Gene:	TG / 7038	HGNCID:	11764	Length:	2768	Species:	Homo sapiens

Alignment Length:	498	Identity:	123/498 - (24%)
Similarity:	191/498 - (38%)	Gaps:	146/498 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPT----QRGLLTREIEG-GEDCLYLNVY 95
            |..:|:|.|||.|.||:||.|.: |:|..|    |.||.    |.|..|....| .||||||||:
Human  2228 FLGVPYAAPPLAERRFQAPEPLN-WTGSWD----ASKPRASCWQPGTRTSTSPGVSEDCLYLNVF 2287

  Fly    96 SKQLKSEKPLPVMVYIYGGAFTVGEATRE----LYGPDYFMTKDVVLVTLNYRVDCLGFLSLKDP 156
            ..|..:.. ..|:|:.:.   |:.....|    :.|.......::::||.:|||...||||  ..
Human  2288 IPQNVAPN-ASVLVFFHN---TMDREESEGWPAIDGSFLAAVGNLIVVTASYRVGVFGFLS--SG 2346

  Fly   157 SLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGG--CSTHFMMCTEQTRGLFHKAI 219
            |.:|.||.||.|||.||.||:.:|..|.||...:::..:..|.  .|.|.:........||.:|:
Human  2347 SGEVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAV 2411

  Fly   220 PMSGTVHNYWANNPAEDFAFRLAQQNGFT-------GENDDAKVLEYLQGVPARDLVNHNLLTPE 277
            .|.|:     |.:||...:...|||....       ..:...:|:..|:..||      |:|...
Human  2412 LMGGS-----ALSPAAVISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPA------NVLNDA 2465

  Fly   278 HRR----NGLLFAFGPTVEAYVGEDCVVPKPPVE-MARDAWSNNFPVMLGGTSFEGLF------- 330
            ..:    :|....:||.::.:     .:.:||.. :.|..|. ...:::|.:..:||.
Human  2466 QTKLLAVSGPFHYWGPVIDGH-----FLREPPARALKRSLWV-EVDLLIGSSQDDGLINRAKAVK 2524

  Fly   331 --------------MYPAVSANL------------------------------KALDSLSQDPTR 351
                          .|.|:..:|                              :||::.::|...
Human  2525 QFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFI 2589

  Fly   352 LVP-VDVRTVSSEKENLEYSQRLMKAYFGYSPP------SSELLLNM-----LDFY--------- 395
            :.| :|:.:.        :::|.....|.|..|      |.|||.::     |.||
Human  2590 ICPIIDMASA--------WAKRARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAYEGQFSL 2646

  Fly   396 -----SYKI--FWHGFNRTFNARLTYAKAPTYYYRFDFDSPNF 431
                 |.||  ::..|.|:.|        |.|.|.|....|.|
Human  2647 EEKSLSLKIMQYFSHFIRSGN--------PNYPYEFSRKVPTF 2681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	123/498 (25%)
TG	NP_003226.4	TY	33..92	CDD:238114
		TY	95..160	CDD:238114
		TY	300..358	CDD:238114
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..545
		Thyroglobulin_1	599..658	CDD:395039
		Thyroglobulin_1	662..724	CDD:395039
		TY	729..>776	CDD:412186
		TY	<892..922	CDD:412186
		TY	1004..1073	CDD:238114
		TY	1077..1145	CDD:238114
		TY	1149..1210	CDD:238114
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:400166
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1996..2129
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	2130..2187
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		123/498 (25%)
		COesterase	2197..2718	CDD:395084	123/498 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2727..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142805
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840