DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and Ces1a

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001177304.1	Gene:	Ces1a / 679817	RGDID:	1583671	Length:	563	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	167/570 - (29%)
Similarity:	240/570 - (42%)	Gaps:	103/570 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GQIKGVKRLSL--YDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEK-------- 72
            |::.| |.:||  :..|...|..:||||||||.|||..|.||:.||.|.:.|.|...
  Rat    31 GKVLG-KYISLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAESWSFVKNATSYPPMCSQITGVG 94

  Fly    73 PTQRGLLTREIEG-----GEDCLYLNVYS-KQLKSEKPLPVMVYIYGGAFTVGEATRELYGPDYF 131
            |....:.|.::|.     .|||||||:|| ..|.|:..|||||:::||....|.|: ...|....
  Rat    95 PVLSEVFTNQLENVPLEYSEDCLYLNIYSPTDLTSKDRLPVMVWVHGGGLLSGGAS-TFDGLALS 158

  Fly   132 MTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGES 196
            ..:.||:|.:.||:...||||..|...:  ||.|..|||.||:||:..|.||.||.:::|:||||
  Rat   159 THEKVVVVVIQYRLGIWGFLSTGDEHSR--GNWGHFDQVAALQWVQNNIVNFGGDPNSVTLFGES 221

  Fly   197 AGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNP----------AEDFAFRLAQQNGFTGEN 251
            |||.|...::.:..|:.|||:||..||.     |..|          ||..|  :|.....|...
  Rat   222 AGGESVSVLVLSPLTKNLFHRAISESGV-----ALTPCLFRENTRLAAEQVA--IATGCAATTSA 279

  Fly   252 DDAKVLEYLQGVPARDLVNHNLLTPEHRRNGLLFAF---GPTVEAY-----VGEDCVVPKPPVEM 308
            |..:.|        |:.....||....:..  .||.   |...|:|     |.:..::||.|.|:
  Rat   280 DIVRCL--------REKTEEELLATTLKMK--FFALDLHGDPRESYPFLTTVIDGVLLPKAPEEI 334

  Fly   309 ARDAWSNNFPVMLGGTSFE-GLFM-----YPAVSANL--KALDSL--SQDPTRLVPVDVRTVSSE 363
            ..:...|..|.::|....| |.|:     ||...:.|  |...||  ...|...:..::..|::|
  Rat   335 LSEKNFNTVPYIVGINKQEFGWFIPTMMGYPLSESKLDQKTATSLLWKSYPLTNISKELTPVATE 399

  Fly   364 KENLEYSQRLMKAYFGYS---PPSSELLLNMLD---FYSYKIFWHGFNRTFNARLTYAKAPTYYY 422
            |            |.|.|   ....:|.|:|:.   |....:....::|.       |:|.||.|
  Rat   400 K------------YLGGSDCPDKKKDLFLDMMGDVLFAVPSVIVARYHRD-------ARATTYVY 445

  Fly   423 RFDFDSPNFNFYRAKFCGD-KIKTGVAHADDLSYLFRNAGSWKLDKTSAEYRTIERMIGIWTAFA 486
            .|.        |...|..| :.||.:|...|..|........|...:..|......|:..|..||
  Rat   446 EFK--------YHPSFVSDMRPKTVIADHGDEVYSVWGTPFLKEGASEEEINLSTMMMKFWGNFA 502

  Fly   487 ATSNPNCPEIGHLEWKPSTKNDPKRVINISSDVTIIDLPEYEKLQIWDNL 536
            ...|||...:.|  |  ...::.:..:.|.:.:......:|:::..|..|
  Rat   503 RNGNPNGEGLPH--W--PEYDEKESYLQIGTTIQQAQKLKYKEVAFWTGL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	163/542 (30%)
Ces1a	NP_001177304.1	COesterase	24..545	CDD:278561	165/565 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336524
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650