DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and Bche

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_075231.1	Gene:	Bche / 65036	RGDID:	619996	Length:	597	Species:	Rattus norvegicus

Alignment Length:	601	Identity:	155/601 - (25%)
Similarity:	253/601 - (42%)	Gaps:	123/601 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMSKESSLETCELTLPVGQIKGVKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLD 65
            :..|..:.|...:|...|:::|:. :.:......:|..||:|:||||.|||:.|.|.:.|..|.:
  Rat    17 LFGKSHTEEDVIITTKTGRVRGLS-MPILGGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDVYN 80

  Fly    66 CTHYAEKPTQR------GLLTREIEG-----GEDCLYLNVYSKQLKSEKPLP------VMVYIYG 113
            .|.||....|.      |....|:..     .||||||||:.       |:|      |||::||
  Rat    81 ATKYANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNVWI-------PVPKPKNATVMVWVYG 138

  Fly   114 GAFTVGEATRELYGPDYFMTK--DVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWV 176
            |.|..|.::..:| ...|:|:  .|::|::||||..||||:....| :.|||.||.||.|||:|:
  Rat   139 GGFQTGTSSLPVY-DGKFLTRVERVIVVSMNYRVGALGFLAFPGNS-EAPGNMGLFDQQLALQWI 201

  Fly   177 KQYISNFNGDDSNITVFGESAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNPAEDFAFR- 240
            ::.|:.|.|:..::|:||||||..|....:...|:..||.:||..||:.:..||....|:...|
  Rat   202 QRNIAAFGGNPKSVTLFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRT 266

  Fly   241 --LAQQNGFTGENDDAKVLEYLQGVPARDLVNHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPK 303
              ||:..|.:.||:...:.......|...|:|..|:.|......:  .|||||:.....|  :|.
  Rat   267 LTLAKFIGCSKENEKEIITCLRSKDPQEILLNEKLVLPSDSIRSI--NFGPTVDGDFLTD--MPH 327

  Fly   304 PPVEMARDAWSNNFPVMLG-----GTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSE 363
            ..:::.:   .....:::|     ||:|   .:|.|        ...|:|...|:
  Rat   328 TLLQLGK---VKTAQILVGVNKDEGTAF---LVYGA--------PGFSKDNDSLI---------- 368

  Fly   364 KENLEYSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHG-----------------FN-----R 406
             ...|:.:.|...:.|.|....|.:|      .|.:.|.|                 :|     .
  Rat   369 -TRREFQEGLNMYFPGVSSLGKEAIL------FYYVDWLGDQTPEVYREAFDDIIGDYNIICPAL 426

  Fly   407 TFNARLTYAKAPTYYYRFDFDS-----PNFNFYRAKFCGDKIKTGVAHADDLSYLFRNAGSWKLD 466
            .|..:....:...::|.|:..|     |.:             .||.|..::.::|......:::
  Rat   427 EFTKKFAELEINAFFYYFEHRSSKLPWPEW-------------MGVMHGYEIEFVFGLPLERRVN 478

  Fly   467 KTSAEYRTIERMIGIWTAFAATSNPNCPEIGHLEWKPSTKNDPKRVINISSDVTIIDLPEYEKL- 530
            .|.||......::..|..||...:||..:.....|...|..:.| .:.::::.:.|:    .||
  Rat   479 YTRAEEIFSRSIMKTWANFAKYGHPNGTQGNSTVWPVFTSTEQK-YLTLNTEKSKIN----SKLR 538

  Fly   531 ----QIWDNLYKPNQL 542
                |.| .|:.|..|
  Rat   539 APQCQFW-RLFFPKVL 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	145/556 (26%)
Bche	NP_075231.1	COesterase	21..545	CDD:278561	150/586 (26%)
		Aes	<120..>272	CDD:223730	60/160 (38%)
		AChE_tetra	560..594	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810