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Protein Alignment alpha-Est5 and BCHE

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_000046.1	Gene:	BCHE / 590	HGNCID:	983	Length:	602	Species:	Homo sapiens

Alignment Length:	569	Identity:	151/569 - (26%)
Similarity:	253/569 - (44%)	Gaps:	102/569 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GQIKGVKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQRGLLTRE 82
            |:::|: .|:::.....:|..||:|:||||.|||:.|.....||.:.:.|.||....|.  :.:.
Human    39 GKVRGM-NLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQN--IDQS 100

  Fly    83 IEG-------------GEDCLYLNVYSKQLKSEKP--LPVMVYIYGGAFTVGEATRELY-GPDYF 131
            ..|             .||||||||:   :.:.||  ..|:::||||.|..|.::..:| |....
Human   101 FPGFHGSEMWNPNTDLSEDCLYLNVW---IPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLA 162

  Fly   132 MTKDVVLVTLNYRVDCLGFLSLK-DPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGE 195
            ..:.|::|::||||..||||:|. :|  :.|||.||.||.|||:||::.|:.|.|:..::|:|||
Human   163 RVERVIVVSMNYRVGALGFLALPGNP--EAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGE 225

  Fly   196 SAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANN---PAEDFAFRLAQQNGFTGENDDAKVL 257
            |||..|....:.:..:..||.:||..||:.:..||..   .|.:....||:..|.:.|| :.:::
Human   226 SAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSREN-ETEII 289

  Fly   258 EYLQGV-PARDLVNHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVML 321
            :.|:.. |...|:|...:.|  ....|...|||||:.    |.:...|.:.:....:... .:::
Human   290 KCLRNKDPQEILLNEAFVVP--YGTPLSVNFGPTVDG----DFLTDMPDILLELGQFKKT-QILV 347

  Fly   322 G-----GTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENLEYSQRLMKAYF-GY 380
            |     ||:|   .:|.|        ...|:|...::        :.||    .|..:|.:| |.
Human   348 GVNKDEGTAF---LVYGA--------PGFSKDNNSII--------TRKE----FQEGLKIFFPGV 389

  Fly   381 SPPSSE-LLLNMLDFYSYKIFWHGFNRTFNAR----------------LTYAKAPTYYYRFDFDS 428
            |....| :|.:..|       |....|..|.|                |.:.|      :|....
Human   390 SEFGKESILFHYTD-------WVDDQRPENYREALGDVVGDYNFICPALEFTK------KFSEWG 441

  Fly   429 PNFNFYRAKFCGDKIK----TGVAHADDLSYLFRNAGSWKLDKTSAEYRTIERMIGIWTAFAATS 489
            .|..||..:....|:.    .||.|..::.::|......:.:.|.||......::..|..||...
Human   442 NNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYG 506

  Fly   490 NPNCPEIGHLEWKPSTKNDPKRVINISSDVT-IIDLPEYEKLQIWDNLY 537
            |||..:.....| |..|:..::.:.::::.| |:.....::.:.|.:.:
Human   507 NPNETQNNSTSW-PVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFF 554

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.