DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est5 and ces2b

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	XP_021326380.1	Gene:	ces2b / 561967	ZFINID:	ZDB-GENE-041014-96	Length:	1611	Species:	Danio rerio

Alignment Length:	536	Identity:	165/536 - (30%)
Similarity:	233/536 - (43%)	Gaps:	87/536 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GQIKGVKRLSLYDDPYF-SFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQRGLLTR 81
            |.:||::..:...|... |:..|||||||:|.||...|.||:.|.||.|.|.......|...|..
Zfish    36 GALKGLQMKARGKDTVIHSYLGIPFAKPPVGPLRLAPPQPAEKWEGVRDATKQPLMCLQDRQLVE 100

  Fly    82 E-----------IEGGEDCLYLNVY--SKQLKSEKPLPVMVYIYGGAFTVGEATRELY-GPDYFM 132
            :           ::..|||||||||  ||..:::| |||||:|:||.||...|:  |: |.....
Zfish   101 DLVANLSAKVDMVDSSEDCLYLNVYTPSKPGRNDK-LPVMVWIHGGGFTTCSAS--LFDGHVLAA 162

  Fly   133 TKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESA 197
            .:|||:|.:.||:..|||.|..|.:  .|||.||.|||.||:||::.|.:|.||..::|:|||||
Zfish   163 YQDVVVVVIQYRLGLLGFFSTGDEN--APGNYGLLDQVAALQWVQENIHSFGGDPGSVTIFGESA 225

  Fly   198 GGCSTHFMMCTEQTRGLFHKAIPMSGT-----VHNYWANNPAEDFAFRLAQQNGFTGEND---DA 254
            ||.|....:.:..:..|||:||..|||     :.|.   ||     ..:||..|.....|   ..
Zfish   226 GGISVSLHVLSPLSANLFHRAIAESGTAAMEAIMNV---NP-----LPIAQAIGNASGCDISSTK 282

  Fly   255 KVLEYLQGVPARDLVNHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPV 319
            |:::.|......:::...:..|       ||.||.|::..     .:|:|..|:.:....|..|:
Zfish   283 KIVDCLMQKSEVEILKITMENP-------LFRFGVTIDGQ-----FLPRPAAELFQSQQFNKVPL 335

  Fly   320 MLGGTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENLEYSQRLMKAYFGYSPPS 384
            |.|.|..|..|:.|........::.|  |...::|: :...:...::....:.|:..|.|.||..
Zfish   336 MTGVTDDEIGFVLPNYLLPPDWINGL--DLESILPL-LTVFNPALQDQSVLELLLNEYLGTSPDR 397

  Fly   385 SEL---LLNML-DFYSYKIFWHGFNRTFNARLTY---AKAPTYYYRFDFDSPNFNFYRAKFCGDK 442
            ..:   ...|| ||.        ||.......:|   |.||.|.|.|..........|..|.|..
Zfish   398 IRIRDGFREMLGDFM--------FNIPARQTASYHRDAGAPVYVYEFRHPPSVLQRKRPSFSGSD 454

  Fly   443 IKTGVAHADDL----SYLFRNAGSWKLDKTSAEYRTIER-MIGIWTAFAATSNPNCPEIGHLEWK 502
                  |.|::    .|.|........:..|.|...:.| .:..|..||.|.|||.|  |...|.
Zfish   455 ------HGDEIVFVFGYCFSEGPIGMAENLSDEEDELCRTTMAYWGNFAHTGNPNGP--GLTSWP 511

  Fly   503 P--------STKNDPK 510
            .        |...|||
Zfish   512 EFGDEAEYLSIGLDPK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	163/534 (31%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:306613	165/536 (31%)
		COesterase	553..1065	CDD:306613
		COesterase	1079..1592	CDD:306613
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820