Protein Alignment alpha-Est5 and NLGN3

DIOPT Version :9

• Sequence 1: NP_001246965.1
• Gene: alpha-Est5 / 40905
• FlyBaseID: FBgn0261393
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 636
• Identity: 161/636 - (25%)
• Similarity: 242/636 - (38%)
• Gaps: 174/636 - (27%)

  Fly    18 GQIKGVKRLSLYDD---PYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEK-PTQRGL 78
            |:::|. |:.|..:   |...:..:|:|.||:||.||..|.|...|||:.:.||:... |.....
Human    49 GKLRGA-RVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHT 112

  Fly    79 LTREI------------------EGGEDCLYLNVY-----SKQLKSE---KP------------- 104
            ...|:                  |..|||||||||     .|::..|   ||
Human   113 AVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAK 177

  Fly   105 ----------------------LPVMVYIYGGAFTVGEATR------ELYGPDYFMTKDVVLVTL 141
                                  .||||||:||::..|....      ..||       :|:::||
Human   178 KQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYG-------NVIVITL 235

  Fly   142 NYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGGCSTHFMM 206
            ||||..|||||..|.:.|  ||.||.||:.||:||.:.|:.|.||...|||||...|......:.
Human   236 NYRVGVLGFLSTGDQAAK--GNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLT 298

  Fly   207 CTEQTRGLFHKAIPMSGTVHNYWANN--PAEDFAFRLAQQNGFTGENDDAKVLEYLQGVPARDLV 269
            .:..:.|||.:||..||:..:.||.|  |.: :...||.:.| ....|...:::.|:...|::||
Human   299 LSHHSEGLFQRAIIQSGSALSSWAVNYQPVK-YTSLLADKVG-CNVLDTVDMVDCLRQKSAKELV 361

  Fly   270 NHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVMLGGTSFEGLFMYPA 334
            ..::....:.     .||||.::   |:  |:|..|..:.......|:.:|||....|||.....
Human   362 EQDIQPARYH-----VAFGPVID---GD--VIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEG 416

  Fly   335 VSANLKALDSLSQDPTRLVPVDVRTVSSEKENLEYSQRLMKAYFGYSPPSSELLLNMLDF-YSYK 398
            |......:.....|         .:||:..:||          :|| |...:.|...:.| |:
Human   417 VVDPEDGVSGTDFD---------YSVSNFVDNL----------YGY-PEGKDTLRETIKFMYT-- 459

  Fly   399 IFWHGFNRTFNARLT--------------------YAK--APTYYYRFDFDSPNFNFYRAKFCGD 441
             .|...:.....|.|                    :|:  :|||:|.         ||.  .|..
Human   460 -DWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYA---------FYH--HCQS 512

  Fly   442 KIK---TGVAHADDLSYLFRNAGSWKLDKTSAEYRTIERMIG-----IWTAFAATSNPNCP---- 494
            .:|   :..||.|::.|:|........|.....:...:.|:.     .||.||.|.:||.|
Human   513 LMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQD 577

  Fly   495 ---------EIGHLEWKPSTKNDPKRVINISSDVTIIDLPEYEKLQIWDNL 536
                     ....:.|......| :..::|.....:.|.....|:..|.:|
Human   578 TKFIHTKANRFEEVAWSKYNPRD-QLYLHIGLKPRVRDHYRATKVAFWKHL 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	156/608 (26%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	159/631 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142584
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740