DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est5 and CG10175

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	190/562 - (33%)
Similarity:	285/562 - (50%)	Gaps:	55/562 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TLPVGQIKGVKRLSLYDD----PYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPT 74
            |..:|:::|  |...|..    .|:||:.:.:..||.|..||||..|..||||:.|.:...:...
  Fly   157 TTSLGKVRG--RYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCP 219

  Fly    75 QRGLLTREIEGGEDCLYLNVYSKQL-----KSEKP-LPVMVYIYGGAFTVGEATRELYGPDYFMT 133
            .:.::....:|.||||::||::.|:     .:|:| |||||:::||.|:.|.....||||||.:.
  Fly   220 HKNMILDTFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSGNSFLYGPDYLVA 284

  Fly   134 KDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAG 198
            :|:||||||||:..||||:....:   |||.||||||||||||:..|:.|.||.:.:|:||||||
  Fly   285 EDIVLVTLNYRLGPLGFLTAGPDA---PGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAG 346

  Fly   199 GCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWA-NNPAEDFAFRLAQQNGFTGENDDAKVLEYLQG 262
            ..|...::.:.|.:||||:||..||:..|.|: :..:...|.|||...|:.|.|....:|::|:.
  Fly   347 ASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGYVGANKTEDILDFLRR 411

  Fly   263 VPARDLVN--HNLLTPEHRRNGLLFAFGPTVEAYVGEDC---------VVPKPPVEMARDAWSNN 316
            |||..||.  ...:|.|.:||.:...|.|.||.|..:|.         .:.:.|.:|..   |.|
  Fly   412 VPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQHPSDMYH---SQN 473

  Fly   317 F----PVMLGGTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENLEYSQRLMKAY 377
            |    ..|.|..:.|.:.....:..|.:.|..:..|..||||.|:....|..   ..::.:...|
  Fly   474 FNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVPQDLNVTESHD---RVTREIRSFY 535

  Fly   378 FGYSPPSSELLLNMLDFYSYKIFWHGFNRTFNARLTYAKAPTYYYRFDFDSPNFNFYRAKFCGDK 442
            .|......|.:..|:...:..:|..|..||......:..||.|.|||.||. :...|: :..|..
  Fly   536 LGSKHVGIESVDEMIALLTDLMFLQGIRRTARNHAKFGNAPVYMYRFSFDG-SLGLYK-RMLGIP 598

  Fly   443 IKTGVAHADDLSYLFR-NAGSWKLDKTSAEYRTIERMIGIWTAFAATSNPNCPE----IGHLEWK 502
             :.||.|.|:|.|||: ...:..||..|.|.:...||:.:||.||...:|. |:    :...:|.
  Fly   599 -RPGVCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRMVRMWTNFAKYGSPT-PDSEDPMLTTKWA 661

  Fly   503 PSTKNDPKRVIN------ISSDVTIIDLPEYEKLQIWDNLYK 538
            |.   ||..|:|      ||:::.:...||.|:.:.||.:|:
  Fly   662 PI---DPTNVMNSLNYMDISANLAMKTNPEPERQRFWDEMYQ 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	179/526 (34%)
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	187/555 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.760