DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and CG4757

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	171/577 - (29%)
Similarity:	267/577 - (46%)	Gaps:	93/577 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SSLETCELTLPVGQIKGVKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWS-GVLDCTHY 69
            ||:.:.|:...:|:::|....|.....:.:|..|.:|:||||:|||..|.|..||| .:.|.:.
  Fly    16 SSVLSIEVDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASE- 79

  Fly    70 AEKPTQRGLLTREIEGGEDCLYLNVYSKQLKSEKPLPVMVYIYGGAFTV--GEATRELYGPDYFM 132
             :.|..........:..||||.||||:|.||..:  ||:|:::.|.|.|  |: ::.|.||::||
  Fly    80 -DGPMCPQPWDNMTDVSEDCLRLNVYTKDLKGRR--PVIVFLHPGGFYVFSGQ-SKYLAGPEHFM 140

  Fly   133 TKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESA 197
            .:|.|||:||||:..||||:  ..|.:.|||||||||||||:|::|:|..|.||..::|:.|.||
  Fly   141 DRDCVLVSLNYRLGSLGFLA--TGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSA 203

  Fly   198 GGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNPA--EDFAFRLA-QQNGF--TGENDDAKVL 257
            |..|....|.:..:|||||:.|.||...:     .|.  :|...:|| :|.|.  ..:....:::
  Fly   204 GSISVALHMLSPMSRGLFHRGICMSAAPY-----GPVKYKDNDLQLAKRQAGLLKCPQESIGEMV 263

  Fly   258 EYLQGVPARDLVNHNLLTPEHRRNGLL-FAFGP------TVEAYVGEDCVVPKPPVEMARDAWSN 315
            |.::..|..|.|:        ..||:. |.:.|      .||...|::..:.:.|.:.||....:
  Fly   264 ECMRRKPYLDYVS--------TYNGMFEFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGDFH 320

  Fly   316 NFPVMLGGTSFE---GLFM-----------------YPAVSANLKALDSLSQDPTRLVPVDVRTV 360
            ...::.|.|.||   |.|.                 |.:::..|:...:.|:..:|:........
  Fly   321 KVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPE 385

  Fly   361 SSEKENLEYSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFNRTFNARLTYAKAPTYYYRFD 425
            |.:|  |||.:.|.    |.....|:.|:.        :.:|.|     .:|.....|.|.|.|.
  Fly   386 SLDK--LEYPKSLK----GMGELLSDALIG--------VSFHRF-----LQLMSPHTPIYTYLFR 431

  Fly   426 FDSPNFNFYRAKFCGDKIKT-GVAHADDLSYLFRNAGSW--KLDKTSAEYRTIERMIGIWTAFAA 487
            :.. .:.|.:..   |..:| |..|.|:|.||| :.|..  .|.:...|...||.:..:|..||.
  Fly   432 YKG-RYTFLKNP---DNQQTIGPVHHDELIYLF-HVGLLIPLLKREDPENFMIELLTRMWIEFAQ 491

  Fly   488 TSNP---NCPEIGHLEWKPSTKNDPKRVINISSDVTI----IDLPEYEKLQIWDNLY 537
            ..:|   |...:..|.| |......|..:.|.:::|.    ..|..|   |||::|:
  Fly   492 KGDPHNKNDEYLKGLNW-PLYNAQDKGYLEIGNNLTAKSGGFFLNRY---QIWEDLF 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	161/543 (30%)
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	168/571 (29%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	75/170 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467407
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.800