DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and alpha-Est2

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	280/544 - (51%)
Similarity:	373/544 - (68%)	Gaps:	13/544 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SSLETCELTLPVGQIKGVKRLSLYD-DPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHY 69
            |:..|..|....||::|::|.::|| :|||:||.||:||||:|:||||||.|.:||.|||:||..
  Fly    28 STGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTN 92

  Fly    70 AEKPTQRGLLTREIEGGEDCLYLNVYSKQLKSEKPLPVMVYIYGGAFTVGEATRELYGPDYFMTK 134
            ..||.||.:|...:||.||||:||||.|.|||||||||:|:||||.|..|||:|::|.|||||.|
  Fly    93 RSKPMQRNMLLGIVEGSEDCLHLNVYVKALKSEKPLPVIVWIYGGGFQKGEASRDIYSPDYFMKK 157

  Fly   135 DVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGG 199
            .||.|.:|||:..|||||||||.|.|||||||||||:||:|:.|.|::||||.:|||:.|||||.
  Fly   158 PVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGS 222

  Fly   200 CSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNPAEDFAFRLAQQNGFTGENDDAKVLEYLQGVP 264
            .|.|.||.||||||||||||..||...:.|..:|..::||||||..|:.|:..||.||.:|..|.
  Fly   223 ASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAFRLAQNLGYKGDEKDADVLSFLSKVC 287

  Fly   265 ARDL--VNHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVMLGGTSFE 327
            ||.:  ::.:::..:..|:.|||||||.:|.|..:.|||||...::..:||.|:.||::||.|||
  Fly   288 ARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFE 352

  Fly   328 GLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSS-EKENLEYSQRLMKAYFGYSPPSSELLLNM 391
            |||.|..|..:..||.:..    .::|.:||..|| |.::| ..:||.:.||......|..:...
  Fly   353 GLFSYQLVRKDPWALKNFH----NILPREVRETSSLEGQDL-LVRRLKQLYFNNEMQESMEMFEA 412

  Fly   392 LDFYSYKIFWHGFNRTFNARLTYA-KAPTYYYRFDFDSPNFNFYRAKFCGDKIKTGVAHADDLSY 455
            |:.:|::..||..:|...||.:|| |.|||.||||||||:||.:|...|||:|: ||||||:|||
  Fly   413 LNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLVCGDRIR-GVAHADELSY 476

  Fly   456 LFRNAGSWKLDKTSAEYRTIERMIGIWTAFAATSNPNCPEIGHLEWK--PSTKNDPKRVINISSD 518
            ||.|..:.||||:|.||:|||||:|:||:||::.||||||:|..:|:  ...:|..::..|||.|
  Fly   477 LFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVEKCFNISHD 541

  Fly   519 VTIIDLPEYEKLQIWDNLYKPNQL 542
            :.:.||||.:.|.:||..|....|
  Fly   542 LEMRDLPESDCLAVWDTFYPRESL 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	266/509 (52%)
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	264/496 (53%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	71/103 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467363
Domainoid	1	1.000	450	1.000	Domainoid score	I1603
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26273
OrthoDB	1	1.010	-	-		D18817at7147
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	12	11.810