DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and alpha-Est8

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	258/533 - (48%)
Similarity:	355/533 - (66%)	Gaps:	17/533 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GQIKGVKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQRGLLTRE 82
            |::||||..|:|.:.|:|||.|||||||:|||||:|||..:.||.|..|||...||.|..::.::
  Fly    40 GKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKRCTHVRAKPCQVNIVLKQ 104

  Fly    83 IEGGEDCLYLNVYSKQLKSEKPLPVMVYIYGGAFTVGEATRELYGPDYFMTKDVVLVTLNYRVDC 147
            ::|.|||||||||:::|...:||||:|:||||.|.:|||:|:||.|||.|.:.||||.::||:..
  Fly   105 VQGSEDCLYLNVYTRELHPHRPLPVLVWIYGGGFQMGEASRDLYSPDYIMMEHVVLVVISYRLGA 169

  Fly   148 LGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGGCSTHFMMCTEQTR 212
            ||||||.|..|.|||||||||||:||:|||:....|.||..|||||||||||.|||:||.|:|.:
  Fly   170 LGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAK 234

  Fly   213 GLFHKAIPMSGTVHNYWANNPAE-DFAFRLAQQNGFTGENDDAKVLEYLQGVPARDL--VNHNLL 274
            |||||.|.|||:....||..|.. ::.:||||..|:||:.:|..:..:|:...|..:  |..:::
  Fly   235 GLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDANDRDIFAHLKKCKASSMLKVAEDII 299

  Fly   275 TPEHRRNGL-LFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVMLGGTSFEGLFMYPAVSAN 338
            |.|.|...| :|:||||:|.|:...||:||.|:||.||.|.|:.|:::||.|||||.|:|.|:..
  Fly   300 TMEERHQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKW 364

  Fly   339 LKALDSLSQDPTRLVPVDVRTVSSEKENLEYSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHG 403
            .:.|..|. |...|.|.|...  .|::...:.:::.:.|||...|..:.:|...|.:|||.||||
  Fly   365 PELLCQLG-DCENLAPQDAHV--DEQQRKAFGKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHG 426

  Fly   404 FNRTFNARLTYAK-APTYYYRFDFDSPNFNFYRAKFCGDKIKTGVAHADDLSYLFRNAGSWKLDK 467
            .:||..:|..:|. |||:.|||||||.:||..|...||.|:: |..|||||||||.||.:.||.:
  Fly   427 IHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGRKVR-GTCHADDLSYLFYNAAAKKLKR 490

  Fly   468 TSAEYRTIERMIGIWTAFAATSNPNCPEIGHLE-------WKPSTKNDPK-RVINISSDVTIIDL 524
            .:||::||:|::.:...||.:.:||.|.:...|       |.|.:|:|.. :.:|||.||.:|||
  Fly   491 RTAEFKTIKRLVSMVVHFAISGDPNIPMVCQDEKEQPRGAWLPISKDDKVFQCLNISHDVHVIDL 555

  Fly   525 PEYEKLQIWDNLY 537
            ||.|||::||.:|
  Fly   556 PEAEKLRLWDCIY 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	242/503 (48%)
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	255/527 (48%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	65/104 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467357
Domainoid	1	1.000	450	1.000	Domainoid score	I1603
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26273
OrthoDB	1	1.010	-	-		D18817at7147
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	11	10.910