DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and Est-Q

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	584	Identity:	162/584 - (27%)
Similarity:	265/584 - (45%)	Gaps:	121/584 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKESSLETCELTLPVGQIKGVKRLSLYDD-PYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDC 66
            :.|::..|.||....|.:.|....:.:.| .:..|..||||:||:.|||||.||...||:|.|:.
  Fly    36 ASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNA 100

  Fly    67 THYAEK-PTQRGLLTREIEGG-EDCLYLNVYSKQLKSEKPLPVMVYIYGGAFTVGEATRELYGPD 129
            .::.:: |....|.::..:.. ||||.|:||:|.|.:.:  |||.|||||.|..|.:  |.:.|:
  Fly   101 LNFGQRCPVITNLDSQMSDAELEDCLTLSVYTKNLSASQ--PVMFYIYGGGFYNGSS--EDHPPN 161

  Fly   130 YFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFG 194
            |.:.||||||...|||..||:||.....|  ||||.:.|.::||.||:.:||:|.||...:|:||
  Fly   162 YLLEKDVVLVVPQYRVGALGWLSTYTEEL--PGNAPIADILMALDWVQMHISSFGGDPQKVTIFG 224

  Fly   195 ESAG-GCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWA-NNPAEDFAFRLAQQNGFTG-ENDD--- 253
            :||| |.::..::..:....:|.:||..||::...|| |...:..:.|:..|.|.:| |..|
  Fly   225 QSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQHDQLV 289

  Fly   254 -----AKVLEYLQGVPARDLVNHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAW 313
                 |||::.|:...:.                   :|.|.|....|   ::|:.|.|:.: ::
  Fly   290 KCIQKAKVIDILKATASE-------------------SFSPIVGDLHG---ILPQQPSELVK-SY 331

  Fly   314 SNNFPVMLGGTSFEGLFM----YPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENLEYSQRLM 374
            ....|::.|.|..:|.|:    |.|::|.:..:.|||   .|.....:..:.::...|
  Fly   332 RRQIPILTGFTQHDGSFVLASYYDALAAKVANVSSLS---VRQFSQGINDLVNDTSGL------- 386

  Fly   375 KAYFGYSPPSSELLLNMLDFYSYKIFWHG--------FNRTFN----------ARLTYAK---AP 418
                      ::.:||.|.|....:..|.        |:.|.|          |...|.:   .|
  Fly   387 ----------TDNILNRLLFKPQALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTP 441

  Fly   419 TYYYRFDFDSP----NFNFYRAKFCGDKIKTGVAHADDLSYLFRNAGSWKLDKTSAEYRTIERMI 479
            .|.|.|:::..    .:.|..:.:   ....||.|::|..|||   .:..|:  ..:.:..::|:
  Fly   442 VYVYSFEYEGTYTRFGYEFGNSHY---PFNGGVHHSNDNIYLF---ATHPLE--GQDTQMSQKMV 498

  Fly   480 GIWTAFAATSNPNCPEIGHLEWKP-STKNDPKRVINISSDVT-----------IIDLPEYEKLQ 531
            .:||:||....|.       ...| |:.:.|...:|:  :||           .||.|:..:||
  Fly   499 DVWTSFAIEGVPR-------NLSPLSSASGPYNKLNL--EVTKGDDLLDTLTAAIDDPDNGRLQ 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	152/546 (28%)
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	156/570 (27%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	48/108 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.970