DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and ces5a

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001265277.1	Gene:	ces5a / 394897	-ID:	-	Length:	565	Species:	Xenopus tropicalis

Alignment Length:	565	Identity:	166/565 - (29%)
Similarity:	241/565 - (42%)	Gaps:	131/565 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LTLPVGQI----KGVKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKP 73
            ||...||:    .|.|..   |.....|..:||||||:|.|||.||.|.:|||.|.:.|  |..|
Frog    35 LTTKYGQLLGNTVGAKET---DRLVHVFMGVPFAKPPIGLLRFEAPQPLEPWSSVREAT--AAPP 94

  Fly    74 ----TQRGL--LTREIEG-------GEDCLYLNVYSKQLKSEKP-LPVMVYIYGGAFTVGEATRE 124
                .:||:  |....:.       .||||||||::...:.|.| |||||:|:||..|:|.|:.
Frog    95 MCLQDKRGMEDLAEFFKAKFDFPPVSEDCLYLNVFTPADRGENPELPVMVFIHGGGLTMGGASM- 158

  Fly   125 LYGPDYFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSN 189
            ..|......::||:|::.||:..:||.|..|.  :|.||.|..|||.||:||:..|.:|.|:..:
Frog   159 FEGTALCAYENVVVVSIQYRLGIMGFFSSGDK--EVRGNFGFLDQVAALQWVRDNIKDFGGNPQS 221

  Fly   190 ITVFGESAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNPAEDFAFRLAQQNG-FTGENDD 253
            :|:|||||||.|....:.:..::|||||||..||                 :|...| .|.:|::
Frog   222 VTIFGESAGGVSVSAQVLSPLSKGLFHKAIAESG-----------------VAILPGLMTSKNEE 269

  Fly   254 ----AKVLEYLQGVPARDLVNHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWS 314
                ..|:..:......|||.......|.....:..|....:...|.:...:|||..|:.....|
Frog   270 ILPLLSVVANISSCSVSDLVGCLKKKTEDEIVAITAAMRFVMFPAVVDGVFLPKPAEEILAAKES 334

  Fly   315 NNFPVMLGGTSFEGLFMYPA---------------VSANLKALDSLSQDPTRLVPVDVRTVSSEK 364
            |..|.::|..:.|..::.|.               :.|.|.||..|            :|||:
Frog   335 NPVPFLIGINNHEFGWILPLALNITGYREGMEKKDIQAILGALPLL------------KTVSN-- 385

  Fly   365 ENLEYSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFNRTFNARLTYAK------APTYYYR 423
                ....:|:.|||.:....||..|.||.....||.....||       ||      .|.|:|.
Frog   386 ----VIPFIMEEYFGDTNDPKELRNNFLDLVGDIIFVIPALRT-------AKYHRDSGLPVYFYE 439

  Fly   424 FD-----FDSPNFNFYRAKFCGDK---------IKTGVAHADDLSYLFRNAGSWK---LDKTSAE 471
            |.     |.....:|.:|.. ||:         :|:|:        ||::.|:.:   |.||..:
Frog   440 FQHRPSMFADSKDDFVKADH-GDELYFVVGGPFLKSGI--------LFKSNGTEEEKILSKTIMK 495

  Fly   472 YRTIERMIGIWTAFAATSNPNCPEIGHLEWKPSTKNDPKRVINIS 516
            |         |..||...:||  .:|..||....:::....||::
Frog   496 Y---------WANFARNGDPN--GLGLAEWPKYDEDEDYLEINLT 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	164/557 (29%)
ces5a	NP_001265277.1	COesterase	28..544	CDD:278561	166/565 (29%)
ces5a	NP_001265277.1	Aes	<128..>231	CDD:223730	44/105 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010