DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and Est-P

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	149/558 - (26%)
Similarity:	243/558 - (43%)	Gaps:	91/558 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ESSLETCELTLPVGQIKGVKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVP-ADPWSGVLDCTH 68
            ||..:...:.:..|:|:| |...|    |:|:|.||.|:.|.|.|||.||.| :..|:.|.:.|.
  Fly    19 ESEADPLIVEITNGKIRG-KDNGL----YYSYESIPNAEHPTGALRFEAPQPYSHHWTDVFNATQ 78

  Fly    69 YAEKPTQRGLLTRE---IEGGEDCLYLNVYSKQLKSEKPLPVMVYIYGGAFTVGEATRELYGPDY 130
            ...:..|......|   :.|.||||.:::|..:..:....||:|.::||||..|..:  :||.|.
  Fly    79 SPVECMQWNQFINENNKLMGDEDCLTVSIYKPKKPNRSSFPVVVLLHGGAFMFGSGS--IYGHDS 141

  Fly   131 FMTKDVVLVT-LNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFG 194
            .|.:..:||. :::.:..|||.|..|..|  |||.|||||.|||:|:|:.|::|.|...||.:.|
  Fly   142 IMREGTLLVVKISFGLGPLGFASTGDRHL--PGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIG 204

  Fly   195 ESAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWA-NNPAEDFAFRLAQQNGFTGENDDAKVLE 258
            .||||.|.|..:..|..:.|...||.:||...:.|. .......||.|.:..|....|..|::.:
  Fly   205 HSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSAELKD 269

  Fly   259 YLQGVPARDLVNHNLLTPEHRRNGLLF------AFGPTVE------AYVGEDCVVPKPPVEMARD 311
            .|:..||.|:|:       ..|:.|:|      ||||.||      |::.||   |:..::..:.
  Fly   270 CLKSKPASDIVS-------AVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTED---PRAVIKSGKF 324

  Fly   312 A---WSNNFPVMLGGTSFEGLFMYPAVSANLKALDSLSQD--------------PTRLVPVDVRT 359
            |   |:..:....||.:          :|.|...:.|:.:              |..|...|.:.
  Fly   325 AQVPWAVTYTTEDGGYN----------AAQLLERNKLTGESWIDLLNDRWFDWAPYLLFYRDAKK 379

  Fly   360 VSSEKENLEYSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFNRTFNARLTYAKAPTYYYRF 424
            ...:.::|.:.  |.:.|......|.|...|:...::..:|.:......:....|.|:|.  |.|
  Fly   380 TIKDMDDLSFD--LRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSPV--YSF 440

  Fly   425 DFDSPNFNFYRAKFCGDK--IKTGVAHADDLSYLFRNAGSWKLDKTSAEYRT---------IERM 478
            .:|:|..:.. .:...::  :..|..|.||...:|          .:|.|||         .::.
  Fly   441 VYDNPTDSGV-GQLLSNRTDVHFGTVHGDDFFLIF----------NTAAYRTGIRPDEEVISKKF 494

  Fly   479 IGIWTAFAATSNPNCPEIGHLEWKPSTKNDPKRVINIS 516
            ||:...| |.::......|...::.:..:...:|:.||
  Fly   495 IGMLEDF-ALNDKGTLTFGECNFQNNVNSKEYQVLRIS 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	144/548 (26%)
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	147/551 (27%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	52/136 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440376
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.790