DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and gas

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	278/546 - (50%)
Similarity:	357/546 - (65%)	Gaps:	23/546 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ETCELTLPVGQIKGVKRLSLYD-DPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEK 72
            :|.||....||:||.:|.:||| :||:|||.||||:||:||||||||.|...|.||.|||:..||
  Fly    31 QTKELATKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCTYAREK 95

  Fly    73 PTQRGLLTREIEGGEDCLYLNVYSKQLKSEKPLPVMVYIYGGAFTVGEATRELYGPDYFMTKDVV 137
            |.||..:|...||.|||||||||:|:|:|.|||||||:|:||.|.||.|:||||||||||..|::
  Fly    96 PMQRNSITNAAEGSEDCLYLNVYAKRLESPKPLPVMVWIFGGGFQVGGASRELYGPDYFMKHDIL 160

  Fly   138 LVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGGCST 202
            |||:||||..||||||||..||:|||||||||:.||:|||:.|::||||..:||||||||||.||
  Fly   161 LVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGESAGGAST 225

  Fly   203 HFMMCTEQTRGLFHKAIPMSGTVHNYWANNPAEDFAFRLAQQNGFTGENDDAK-VLEYLQGVPAR 266
            |.:|.|||.|||||:||..||:....||..|...:..||.::.|:.|..:..| :||:.|.:||.
  Fly   226 HILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQRLGKELGYAGNLESEKELLEFFQQIPAS 290

  Fly   267 DLVNH--NLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVMLGGTSFEGL 329
            .|..:  :::|.|.:|:..:.||.|.:|.|||:|||:||...|....||.|:.|:::||||||||
  Fly   291 KLAQYCNSIVTQEEQRDYEILAFAPVIEPYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGL 355

  Fly   330 FMYPAVSANLKALDSLSQDP-------TRLVPVDVRTVSSEKENLEYSQRLMKAYFGYSPPSSEL 387
            |.|..      .||    ||       ..::|..||....::|..|..:||.|:||.....:|..
  Fly   356 FSYRT------TLD----DPLYMLSAFEAIIPKQVRDAIDKEELAEMVRRLKKSYFDDPDRASME 410

  Fly   388 LLNMLDFYSYKIFWHGFNRTFNARLTYA-KAPTYYYRFDFDSPNFNFYRAKFCGDKIKTGVAHAD 451
            |...|...|.|.|||..:||..|||.|| ..|||.||||.|||:||.||...||.|:: ||.|||
  Fly   411 LYECLHILSIKNFWHDIHRTLLARLAYATNLPTYLYRFDMDSPHFNHYRILKCGKKVR-GVCHAD 474

  Fly   452 DLSYLFRNAGSWKLDKTSAEYRTIERMIGIWTAFAATSNPNCPEIGHLEWKPSTKNDPKRVINIS 516
            |:||:|....|.||||.|.|||||||::|:||:||.|.:|||..|..::|.|......:..:||:
  Fly   475 DISYMFYGILSSKLDKNSPEYRTIERLVGMWTSFATTGDPNCEIIAPVKWDPLRPGGVENCLNIA 539

  Fly   517 SDVTIIDLPEYEKLQIWDNLYKPNQL 542
            ..:..|.|||.::..:||:.|....|
  Fly   540 DGLEFIPLPESKQFVVWDSFYTRESL 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	268/512 (52%)
gas	NP_611678.1	COesterase	28..534	CDD:278561	268/513 (52%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	74/104 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467359
Domainoid	1	1.000	450	1.000	Domainoid score	I1603
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26273
OrthoDB	1	1.010	-	-		D18817at7147
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	12	11.810