DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est5 and CG3841

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	559	Identity:	157/559 - (28%)
Similarity:	239/559 - (42%)	Gaps:	95/559 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LPVGQIKGVKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSG-VLDCTHYAEKPTQRGL 78
            |.:|:|:|....|..:...::|..|.:|:.|:|:|||..|||...|.. |.:.|..:....|.|:
  Fly    33 LSLGRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLVCPQPGV 97

  Fly    79 LTREIEGGEDCLYLNVYSKQLKSEKPLPVMVYIYGGAFTVG------EATRELYGPDYFMTKDVV 137
            ::..   .||||.:||::|..  |...||||||:|||..:|      ||     ||.|.:.:|||
  Fly    98 VSLM---SEDCLKINVFTKSF--EDKFPVMVYIHGGANVLGSGHSSYEA-----GPQYLLDQDVV 152

  Fly   138 LVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGGCST 202
            .|..|||:..|||||......|  ||.|..|||:||:||:.:||:|.||...:|:.|.|||..:.
  Fly   153 FVAFNYRLGALGFLSTNSSETK--GNFGFLDQVMALEWVRDHISHFGGDPELVTIIGISAGSMAV 215

  Fly   203 HFMMCTEQTRGLFHKAIPMSGTVHN-------YWANNPAEDFAFRLAQQNGFTG--ENDD-AKVL 257
            ...:.:..:.||||:||.|||:..|       :|....|.:....:........  .|:. .:::
  Fly   216 SLHLASPLSAGLFHRAILMSGSATNHFDIDNLFWTRKLARELGCPMYDPTDVVECLRNETWTRIV 280

  Fly   258 EYLQGVPARDLVN------------HNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMAR 310
            |..:......|||            ||     |                          |.|:.:
  Fly   281 EVCKAWETYQLVNMKWNYEIDGHFLHN-----H--------------------------PTELIK 314

  Fly   311 DAWSNNFPVMLGGTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENLEYSQRLMK 375
            :...|..|:::..|:.|  |.|.| :.:|:....|....:..|.. ...:...:.:.:..::|..
  Fly   315 EGNFNKVPLLISFTANE--FDYNA-NVHLENQHLLHDFASNFVDY-APELFLYRHDAQIGEKLKD 375

  Fly   376 AYFGYSPP--SSELLLNMLDFYSYKIFWHGFNRTFNARLTYAKAPTYYYRFDFDSPNFNFYRAKF 438
            .|.|.:..  :||.:.|....:|.....||.:|.  .:|.....|.||.|.|:...  ....|..
  Fly   376 FYLGDNTTEINSENIENFGQIFSDAYIGHGVHRL--VQLASHFTPVYYTRMDYVGD--QSLSAPL 436

  Fly   439 CGDKIKTGVAHADDLSYLFRNAGSW---KLDKTSAEYRTIERMIGIWTAFAATSNP-NCPEIGHL 499
            .|:....||.|||||.|:.  .|.|   .:....::...:||:...:|.||.|..| |..:|
  Fly   437 NGENKPVGVGHADDLHYVL--PGYWYGPLMAANDSDVFMMERLTSWFTHFAKTGTPLNSTDI--- 496

  Fly   500 EWKPSTKNDPKRVINISSDVTIIDLPEY-EKLQIWDNLY 537
             |.|......|.:.|  ..||.:..|.| .:..:||.|:
  Fly   497 -WPPCNSTVLKMLYN--GVVTQVGSPGYSNRYAVWDKLF 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	148/529 (28%)
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	154/553 (28%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	55/125 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467408
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.890