DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and CG9289

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_609245.1	Gene:	CG9289 / 34195	FlyBaseID:	FBgn0032058	Length:	674	Species:	Drosophila melanogaster

Alignment Length:	586	Identity:	171/586 - (29%)
Similarity:	240/586 - (40%)	Gaps:	137/586 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TLP-VGQIKGVKRLSLYD---DPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTH-YAEKP 73
            |:| :|:::|  |....|   .....|..||:.|..    |||...||..|.|||.... :|..|
  Fly    79 TVPDLGRLRG--RTLTTDWTGQKIMQFLDIPYGKAE----RFRPAEPAPSWKGVLPAHRPHAGCP 137

  Fly    74 TQRGLL--TREIEGG---EDCLYLNVYSKQLKSEKPLPVMVYIYGGAFTVGEATRELYGPDYFMT 133
            :.:.|:  .:..|.|   ||||.|:|.:|.::. |.|||||||:|..|..|::...  .|.|.:.
  Fly   138 SIQDLIVFAKLEEDGFDVEDCLRLSVNTKAMEG-KSLPVMVYIHGDFFYDGDSVEA--APGYLLE 199

  Fly   134 KDVVLVTLNYRVDCLGFLS-LKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESA 197
            .|||||::.||:...|||| |.|   ::||||.:.|.:||||||:|:|::|.||...:|:||:..
  Fly   200 HDVVLVSVRYRLGPFGFLSTLTD---EMPGNAAVTDIILALKWVQQHIASFGGDPQRVTLFGQVG 261

  Fly   198 GGCSTHFMMCTEQT-RGLFHKAIPMSGTVHNYWANNPA--EDFAFRLAQQNG-FTGENDDAKVLE 258
            |....:.:..:... .||||:.|..|||     |.:||  .|......:..| ..|.....||
  Fly   262 GAALVNVLTLSPAVPAGLFHRVIYQSGT-----ALSPAFITDAPLGATKAIGRIAGCKQSTKV-- 319

  Fly   259 YLQGVPARDLVNHNLLTPEHRRNG--LLFAFG------PTVE--AYVGEDCVV-------PKPPV 306
                    |.:|..|    :|.|.  ||.||.      |::.  ||.|...|:       |:.|.
  Fly   320 --------DQLNKCL----NRLNATMLLAAFSVHGENQPSLSGGAYGGVQLVIGGPSGILPEHPG 372

  Fly   307 EMARDAWSNNFPVMLGGTSFEGLFMYPAVSA---NLKALDSLSQDPTRLVPVDVRTVSSEKENLE 368
            .:........:|.|.|.....|.||...:.|   |...||            |..|      ..:
  Fly   373 RLLAAEKFQAYPTMGGSVKHGGTFMLRDIFADIFNETILD------------DTMT------GRQ 419

  Fly   369 YSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHG--FNRTFNARLT------------------ 413
            |...:::...|..|..|     ..:|...:||...  .|.||. |||
  Fly   420 YIDTIIEQANGADPSGS-----WKEFSDEEIFTQNDVKNGTFK-RLTPGLIDLCSTISLKNPVLL 478

  Fly   414 -----YAKAP--TYYYRFDFDSPNFNFY-----RAKFCGDKIKTGVAHADDLSYLFRNAGSWK-- 464
                 ..|.|  ||.|.||::... |.|     .|.|.  ....||:..||..|||    .|.
  Fly   479 VLQANAKKLPNSTYLYSFDYEGEQ-NRYATGEDEANFV--PFDMGVSLTDDNLYLF----PWPRF 536

  Fly   465 -LDKTSAEYRTIERMIGIWTAFAATSNPNCPEIGHLEWKPSTKNDPKRVINISSDVTIID--LPE 526
             ...::.:.:...||:.:||:||.|..|..|  |...| |:..::....:.|...|:..|  |.|
  Fly   537 LALNSNRDLKVARRMVALWTSFATTGVPQAP--GLPAW-PAMNDETGPYMKIDRTVSFGDNYLDE 598

  Fly   527 Y 527
            |
  Fly   599 Y 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	165/565 (29%)
CG9289	NP_609245.1	COesterase	83..600	CDD:278561	169/582 (29%)
CG9289	NP_609245.1	Aes	<171..351	CDD:223730	72/203 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467447
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850