DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est5 and CG6414

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	168/521 - (32%)
Similarity:	244/521 - (46%)	Gaps:	92/521 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SFEKIPFAKPPLGELRFRAPVPADPWSG----VLDCTHYAEK-PTQRGLLTREIEGGEDCLYLNV 94
            :|..:|:|:|||.:||||.|||..||.|    :.|.....:: |.:|.::   :||.||||||||
  Fly    55 AFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQRDPFRRDMI---LEGSEDCLYLNV 116

  Fly    95 YSKQLKSEKP-----LPVMVYIYGGAFTVGEATRELYGPDYFMTKDVVLVTLNYRVDCLGFLSLK 154
            |:    .|:|     |||||:.:||.:..|......||||:.:..|:|||:.|:|:..|||||.:
  Fly   117 YT----PERPRTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTE 177

  Fly   155 DPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGGCSTHFMMCTEQTRGLFHKAI 219
              :|..|||.|||||:..|.||:..|::|.||.:::|||||||||.|..:.|.:|::|||.|:.|
  Fly   178 --TLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGI 240

  Fly   220 PMSGTVHNYWA----NNPAEDFAFRLAQQNGFTGENDDAKVLEYLQGVPARDLVNHNLLTPEHRR 280
            ..|||..|.||    ...|...|.:|||..|.....:..:.||.|:..||.|:|
  Fly   241 AQSGTYFNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRKKPAEDIV----------- 294

  Fly   281 NGLLFAFGPTVEAYVGE-DCVVPKPPV--------------EMARDAWSNNFPVMLGGTSFEGLF 330
                   ....:.:|.: |.::|.|||              ..|........|:|:|.|:.|||.
  Fly   295 -------ASLYDMFVWDFDPMIPFPPVVEPEHDGAFLTVAPRQAAKPHGLQLPLMVGATAEEGLL 352

  Fly   331 MYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENLE--YSQRLMKAYF----GYSPPSSELLL 389
            ...|:....:.|........:::|| |.......:::.  .:||:...||    .|...:.:
  Fly   353 KTAALLNLPQLLAEFKSQFEQVLPV-VLNYDHHDDSVRQTITQRIESFYFKSGHDYDKANHQ--- 413

  Fly   390 NMLDFYSYKIFWHGFNRTFNARLTYAK-APTYYYRFD----------FDSPNFNFYRAKFCGDKI 443
            |:.|..|...|..|.:.....|::... ||||.|.||          |......||
  Fly   414 NLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFY--------- 469

  Fly   444 KTGVAHADDLSYLFRNAGSWKLD--KTSAEYRTIERMIGIWTAFAATSNPNCPEIG-HL-EWKPS 504
              |..||::|.|||.......:.  .|..:....|.|:.:|.:||.|.|||...:. || .|.|:
  Fly   470 --GACHAEELQYLFPIGRELFVSAVPTQKDLELRELMLHLWVSFAKTGNPNPTNVSFHLPNWSPA 532

  Fly   505 T 505
            :
  Fly   533 S 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	168/521 (32%)
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	168/521 (32%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	66/143 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.760