DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and CES4A

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	XP_011521323.1	Gene:	CES4A / 283848	HGNCID:	26741	Length:	628	Species:	Homo sapiens

Alignment Length:	599	Identity:	166/599 - (27%)
Similarity:	260/599 - (43%)	Gaps:	115/599 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GQIKGVKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHY------AEKP--- 73
            |.::| |::.:...|...|..:||::||||.|||..|.|.:||.|:.|.|.|      |..|
Human    57 GTLQG-KQMHVGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGWSLALSPGWS 120

  Fly    74 --------------TQRGLL-------------------------TRE----IEGGEDCLYLNVY 95
                          .|..||                         |||    :...|||||||||
Human   121 AVARSRLTATSASRVQASLLPQPLSIWGYRCLQESWGQLASMYVSTRERYKWLRFSEDCLYLNVY 185

  Fly    96 S-KQLKSEKPLPVMVYIYGGAFTVGEATRELYGPDYFMTKDVVLVTLNYRVDCLGFLSLK---DP 156
            : .:...:..|||||:..||||.||.|: ...|.|....:.||||.|.:|:...|||..:   |.
Human   186 APARAPGDPQLPVMVWFPGGAFIVGAAS-SYEGSDLAAREKVVLVFLQHRLGIFGFLRWRGRTDD 249

  Fly   157 SLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGGCSTHFMMCTEQTRGLFHKAIPM 221
            | ...||.||.||:.||:||::.|:.|.||..|:|:||:|||..|...:|.:....||||:||..
Human   250 S-HARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLFHRAISQ 313

  Fly   222 SGTV--HNYWANNPAEDFAFRLAQQNGFTGENDDAKV--LEYLQGVPARDLVNH-NLLTPEHRRN 281
            |||.  ..:..:||.: .|.::|...|....:....|  |..|.|.....:.|. ..|....:|:
Human   314 SGTALFRLFITSNPLK-VAKKVAHLAGCNHNSTQILVNCLRALSGTKVMRVSNKMRFLQLNFQRD 377

  Fly   282 --GLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVMLGGTSFEGLFMYPAV---SANLKA 341
              .::::..|.|:.     .|:|..|:.:......::.|.:||..:.|..::.|.:   ..|.:|
Human   378 PEEIIWSMSPVVDG-----VVIPDDPLVLLTQGKVSSVPYLLGVNNLEFNWLLPYIMKFPLNRQA 437

  Fly   342 LDSLSQDPTRLVPVDVRTVSSEKENLEYSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFNR 406
            :  ..:..|:::......::..||.:              |...|..|:.::.:.:|:.   .||
Human   438 M--RKETITKMLWSTRTLLNITKEQV--------------PLVVEEYLDNVNEHDWKML---RNR 483

  Fly   407 TF----NARLTYAKAPTYYYRFDFDSPNFNF---YRAKFCGDKIKT-GVAHADDLSYLFRNAGSW 463
            ..    :|...||...|.:|..|...|.:.:   :.|:....|.:| |..|.|::.:||  .|.:
Human   484 MMDIVQDATFVYATLQTAHYHRDAGLPVYLYEFEHHARGIIVKPRTDGADHGDEMYFLF--GGPF 546

  Fly   464 KLDKTSAEYRTIE-RMIGIWTAFAATSNPNCPEIGHLEWKPSTKNDPKRVINISSDVTI---IDL 524
            ....:..:.:.:. :|:..|..||.|.|||   .|:|...|....|.|   .:..|.|.   :.|
Human   547 ATGLSMGKEKALSLQMMKYWANFARTGNPN---DGNLPCWPRYNKDEK---YLQLDFTTRVGMKL 605

  Fly   525 PEYEKLQIWDNLYK 538
            .| :|:..|.:||:
Human   606 KE-KKMAFWMSLYQ 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	157/566 (28%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	163/592 (28%)
CES4A	XP_011521323.1	Aes	<184..>291	CDD:223730	47/108 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142754
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.700