DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and Tg

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_112250.2	Gene:	Tg / 24826	RGDID:	3848	Length:	2768	Species:	Rattus norvegicus

Alignment Length:	585	Identity:	139/585 - (23%)
Similarity:	226/585 - (38%)	Gaps:	163/585 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMSKESSL--ETCELTL-------------PVGQIKGVKRLSLYDDPY----------------- 33
            :.|.|.||  :||.|.|             |:.|..|:...|::.|.:
  Rat  2160 IQSCEHSLRSKTCWLLLHEEAAYIYRKSGAPLHQSDGISTPSVHIDSFGQLQGGSQVVKVGTAWK 2224

  Fly    34 --FSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQRGLLT-REIEGGEDCLYLNVY 95
              :.|..:|:|.|||.|.||:||...: |:|..|.|.......|.|..| ...:..||||||||:
  Rat  2225 QVYQFLGVPYAAPPLAENRFQAPEVLN-WTGSWDATKLRSSCWQPGTRTPTPPQISEDCLYLNVF 2288

  Fly    96 -SKQLKSEKPLPVMVYIY--------GGAFTVGEATRELYGPDYFMTKDVVLVTLNYRVDCLGFL 151
             .:.|.|.  ..|:|:.:        ||...:..:.....|       ::::||.|||:...|||
  Rat  2289 VPENLVSN--ASVLVFFHNTVEMEGSGGQLNIDGSILAAVG-------NLIVVTANYRLGVFGFL 2344

  Fly   152 SLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGG--CSTHFMMCTEQTR-G 213
            |  ..|.:|.||.||.|||.||.||:.:|..|.||...:|:..:..|.  .|.| ::.|..|| .
  Rat  2345 S--SGSDEVAGNWGLLDQVAALTWVQTHIGAFGGDPQRVTLAADRGGADVASIH-LLITRPTRLQ 2406

  Fly   214 LFHKAIPMSGTVHNYWANNP--------AEDFAFRLAQQNGFTGENDDAKVLEYLQGVPARDLVN 270
            ||.||:.|.|:     |.:|        |:..|..||::.|....:.. :|:...:..||
  Rat  2407 LFRKALLMGGS-----ALSPAAIISPDRAQQQAAALAKEVGCPNSSVQ-EVVSCFRQKPA----- 2460

  Fly   271 HNLLTPEHRR----NGLLFAFGPTVEA-YVGEDCVVP----KPPVEMARDAWSNNFPVMLGGTSF 326
             |:|.....:    :|....:||.|:. |:.|   :|    |.|:.:..|       :::||:..
  Rat  2461 -NILNEAQTKLLAVSGPFHYWGPVVDGQYLRE---LPSRRLKRPLPVKVD-------LLIGGSQD 2514

  Fly   327 EGLF---------------------MYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENLEYS 370
            :||.                     .|.|:..:|...||    ..|::...:...|.|....:|:
  Rat  2515 DGLINRAKAVKQFEESQGRTNSKTAFYQALQNSLGGEDS----DARILAAAIWYYSLEHSTDDYA 2575

  Fly   371 ------QRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFNRTFNARLTYAKAPTYYYRFDFDSP 429
                  :...:.||...|     ::||...:              ||.|......|:....:...
  Rat  2576 SFSRALENATRDYFIICP-----IVNMASLW--------------ARRTRGNVFMYHVPESYGHG 2621

  Fly   430 NFNFYRAKFCGDKIKTGVAHADDLSYLFRNAGSWKLDKTSAEYRTIERMIGIWTAFAATSNPNCP 494
            :.          ::...|.:|..|.:.....|.:.:::.|...:.::    .::.|..:.|||.|
  Rat  2622 SL----------ELLADVQYAFGLPFYSAYQGYFSMEEQSLSLKVMQ----YFSNFIRSGNPNYP 2672

Fly 495 494
Rat 2673 2672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	137/579 (24%)
Tg	NP_112250.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	164..249	CDD:294100
		TY	301..359	CDD:238114
		TY	<613..658	CDD:238114
		TY	661..724	CDD:238114
		TY	730..>776	CDD:294100
		TY	<893..922	CDD:238114
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1455..1468
		GCC2_GCC3	1464..1509	CDD:285001
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1469..1485
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1486..1502
		TY	1519..1566	CDD:214561
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1602..1722
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1723..1891
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1892..1994
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1995..2127
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	2128..2185		8/24 (33%)
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		131/557 (24%)
		COesterase	2198..2719	CDD:278561	128/547 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2731..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336494
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930