DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and Ces2a

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	151/570 - (26%)
Similarity:	237/570 - (41%)	Gaps:	125/570 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GQIKG----VKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQRGL 78
            ||::|    ||...   ....:|..|||||||:|.|||..|...:|||||.|.|.......|..:
  Rat    39 GQVRGSFVHVKDTK---SGIHTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTDI 100

  Fly    79 LTREIEG-------------GEDCLYLNVYS-KQLKSEKPLPVMVYIYGGAFTVGEATRELYGPD 129
            :  .::|             .|||||||:|: ...:....|||||:|:||...:|.|:.. ....
  Rat   101 M--NLDGIKEMKLTVHPTPMSEDCLYLNIYTPAHAREGSNLPVMVWIHGGGLVLGSASMN-DAST 162

  Fly   130 YFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFG 194
            ...|:::|:|::.||:..|||.|..|.:.:  ||.|..|||.||:||:|.|:.|.|:...:|:||
  Rat   163 LAATEEIVIVSIQYRLGVLGFFSTGDQNAR--GNWGYLDQVAALRWVQQNIAYFGGNHGKVTIFG 225

  Fly   195 ESAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNPAEDFAFR-LAQQNGFTGENDDA---- 254
            .||||.|....:.:..::||||.||..||........:...:..:: :|..:|....:.:|
  Rat   226 GSAGGTSVSSHVVSPMSKGLFHGAIMQSGVALLPDLISDKSEVVYKTVANLSGCEAPDSEALIRC 290

  Fly   255 -------------KVLEYLQGVPARDLVNHNLLTPEHRRNGLLFAFG-----PTVEAYVGEDCVV 301
                         :|.:.:.||     |:...| |:|.:.  |.|.|     |::.....::|
  Rat   291 LRAKSKQEILAINQVFKMIPGV-----VDGKFL-PKHPQE--LLASGDFHPVPSIIGINTDEC-- 345

  Fly   302 PKPPVEMARDAWSNNFPVMLGGTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKEN 366
                      .|  ..||.||............:...||:..:....|...:.:.:.....:.||
  Rat   346 ----------GW--GIPVFLGLDHIIKKITRETLPTVLKSTAAQMMLPPECIDLIMEEYMGDTEN 398

  Fly   367 LEYSQ---RLMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFNRTFNARLTYAKAPTYYYRFDFDS 428
            .|..|   |.|...|.:..|:.::                      |....::||.|:|.|. ..
  Rat   399 PETLQEQFRHMLGDFMFVIPALQV----------------------AHFQRSQAPVYFYEFQ-HL 440

  Fly   429 PNFNFYRAKFCGDKIK------TGVAHADDLSYLFRNAGS--WKL--DKTSAEYRTIERMIGIWT 483
            |:|           ||      ....|.||:.::|   ||  |.:  |.|..|.....|::..|.
  Rat   441 PSF-----------IKQVRPSHVKADHGDDILFVF---GSYLWGMTFDLTEEEELLKRRVMKYWA 491

  Fly   484 AFAATSNPNCPEIGHLEWKPSTKNDPKRVINISSDVTIIDLPEYEKLQIW 533
            .||.|.|||..::.|  | |...:| ::.:.:::...:....:..:||.|
  Rat   492 NFARTGNPNGEDLPH--W-PVLDHD-EQYLQLNTQPAVGRALKARRLQFW 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	148/545 (27%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	150/568 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336223
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840