DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est5 and Ces1c

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	XP_006255234.2	Gene:	Ces1c / 24346	RGDID:	2571	Length:	551	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	168/578 - (29%)
Similarity:	260/578 - (44%)	Gaps:	88/578 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SSLETCEL-------TLPV-----GQIKGVKRLSL--YDDPYFSFEKIPFAKPPLGELRFRAPVP 56
            :||..|.:       :.||     |::.| |.:||  :..|...|..:||||||||.|||..|.|
  Rat     9 ASLAACPIWASGHPSSPPVVDTTKGKVLG-KYVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPEP 72

  Fly    57 ADPWSGVLDCTHYAEKPTQRGLLTR-------------EIEGGEDCLYLNVYS-KQLKSEKPLPV 107
            |:|||.|.:.|.|....:|.|::.:             .:|..|||||||:|| ..|.....|||
  Rat    73 AEPWSFVKNTTTYPPMCSQDGVVGKLLADMLSTGKENIPLEFSEDCLYLNIYSPADLTKNSRLPV 137

  Fly   108 MVYIYGGAFTVGEATRELYGPDYFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLA 172
            ||:|:||...:|.|: ...|......::||:||:.||:...|..|..|...:  ||....||:.|
  Rat   138 MVWIHGGGLIIGGAS-PYSGLALSAHENVVVVTIQYRLGIWGLFSTGDEHSR--GNWAHLDQLAA 199

  Fly   173 LKWVKQYISNFNGDDSNITVFGESAGGCSTHFMMCTEQTRGLFHKAIPMSGTV--HNYWANNPAE 235
            |:||:..|:||.|:..::|:|||||||.|...::.:...:.|||:||..||.|  .|....| .:
  Rat   200 LRWVQDNIANFGGNPDSVTIFGESAGGVSVSVLVLSPLAKNLFHRAISESGVVLTTNLDKKN-TQ 263

  Fly   236 DFAFRLAQQNGFTGENDDAKVLEYLQGVPARDLVNHNLLTPEHRRNGLLFAFGPTVEAYVGEDCV 300
            ..|..:|..:| ......|.:::.|:.....:|:.            |......|..:.|.:..|
  Rat   264 AVAQMIATLSG-CNNTSSAAMVQCLRQKTEAELLE------------LTVKLDNTSMSTVIDGVV 315

  Fly   301 VPKPPVEMARDAWSNNFPVMLGGTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKE 365
            :||.|.|:..:...|..|.::|....|..::.|.:..||.:...:::   ::....:|..|   .
  Rat   316 LPKTPEEILTEKSFNTVPYIVGFNKQEFGWIIPTMMGNLLSEGRMNE---KMASSLLRRFS---P 374

  Fly   366 NLEYSQRLMKAYF-----GYSPPS--SELLLNMLDFYSYKIFWHGFNRTFNAR-LTYAKAPTYYY 422
            ||..|:.::.|..     |...|:  .||||:|..    .:|: |......:| |..|.||||.|
  Rat   375 NLNISESVIPAIIEKYLRGTDDPAKKKELLLDMFS----DVFF-GIPAVLMSRSLRDAGAPTYMY 434

  Fly   423 RFDFDSPNFNFYRAKFCGDKIKTGVA--HADDLSYLFRNAGSWKLDKTSAEYRT-IERMI-GIWT 483
            .|.        ||..|..|:....|.  |.|::..:|   |:..|.:.::|..| :.::: ..|.
  Rat   435 EFQ--------YRPSFVSDQRPQTVQGDHGDEIFSVF---GTPFLKEGASEEETNLSKLVMKFWA 488

  Fly   484 AFAATSNPNCPEIGHLEWKPSTKNDPKR-VINISSDVTIIDLPEYEKLQIWDNLYKPN 540
            .||...|||...:.|  |   .:.|.|. .:.|.:........:.|::..|..|...|
  Rat   489 NFARNGNPNGEGLPH--W---PEYDQKEGYLQIGATTQQAQKLKGEEVAFWTELLAKN 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	162/544 (30%)
Ces1c	XP_006255234.2	COesterase	24..534	CDD:395084	162/554 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720