DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and Ces4a

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_666325.2	Gene:	Ces4a / 234677	MGIID:	2384581	Length:	563	Species:	Mus musculus

Alignment Length:	559	Identity:	167/559 - (29%)
Similarity:	251/559 - (44%)	Gaps:	82/559 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GQIKGVKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQRG----- 77
            |.::| |::.:.|.|...|..|||:|||:|..||..|.|..||:|:.|.|.|.....|..
Mouse    41 GILQG-KQVHVGDTPIQVFLGIPFSKPPVGTRRFAPPEPPLPWNGIRDATTYPPSCLQESWGQIL 104

  Fly    78 ---LLTRE----IEGGEDCLYLNVYSKQLKSEKP-LPVMVYIYGGAFTVGEA-TRELYGPDYFMT 133
               |.||:    :...|||||||||:..|....| |||||:..||||..|.| |.|  |.:....
Mouse   105 SMYLNTRKQYKWLHFSEDCLYLNVYAPVLAPGAPLLPVMVWFPGGAFLAGSASTYE--GSELAAR 167

  Fly   134 KDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAG 198
            ..||||.|.||:..|||.|..:...:  ||.||.||:.||:||::.|..|.||..::|:||:|||
Mouse   168 GKVVLVFLQYRLGILGFFSTGNSHAR--GNWGLLDQIAALRWVQENIEAFGGDPDSVTLFGQSAG 230

  Fly   199 GCSTHFMMCTEQTRGLFHKAIPMSGT--VHNYWANNPAEDFAFRLAQQNGFTGENDDAKVL-EYL 260
            ..|...:|.:...:||||:||..|||  :..:...:|... |.::|...|.  :::..||: |.|
Mouse   231 AMSVSGLMVSPLAQGLFHQAISQSGTAVLKAFITPDPLTS-AKKIAHLAGC--DHNSTKVMVECL 292

  Fly   261 QGVPARD--LVNHNL---LTPEHR-RNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPV 319
            :.:.|.:  ||:..:   ....|: ...:::...|.|:.     .|.|:.||.:.........|.
Mouse   293 RSLSAEEVTLVSKRMSFFQANSHKDPKEIVWFLSPVVDG-----VVFPEDPVVLLTRGQVKPVPY 352

  Fly   320 MLGGTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTV--------SSEKENLEYSQRLMKA 376
            :||..:.|  |.:     ||..|..:..:...:...::..:        :..||.:....|
Mouse   353 LLGVNNAE--FEW-----NLPFLMKIQLNQRMMNQTNINKILWSFNVLLNITKEQVPVVAR---- 406

  Fly   377 YFGYSPPSSELLLNMLDFYSYKIFWHGFNRTF----NARLTYAKAPTYYYRFDFDSP--NFNFYR 435
                     |.|.:.:..:.:|:|   .||..    :|...||......|..|..||  .:.|..
Mouse   407 ---------EYLNDAISNHDWKMF---RNRLIDLIGDATFVYATLQAARYHRDAGSPVYLYEFKH 459

  Fly   436 AKFCGDKIK--TGVAHADDLSYLFRNAGSWKLDKTSAEYRTIERMIGIWTAFAATSNPNCPEIGH 498
            ....|..||  .|..|.|:|||||.:..| |......|.....:|:..|..||.|.|||..::.:
Mouse   460 HASSGIIIKPYNGADHGDELSYLFGSPFS-KGSSAGEEKEFSLQMMKYWANFAHTGNPNGEKLPY 523

  Fly   499 LEWKPSTKNDPKRVINISSDVTI-IDLPEYEKLQIWDNL 536
              |....|::  :.:.:..|..: :.|.| :|:..|..|
Mouse   524 --WPRFDKDE--KYLQLDFDTRVGVKLKE-KKMAFWSQL 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	161/530 (30%)
Ces4a	NP_666325.2	COesterase	30..554	CDD:278561	165/554 (30%)
Ces4a	NP_666325.2	Aes	<128..>272	CDD:223730	61/148 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832842
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650