Protein Alignment alpha-Est5 and Ces2c

DIOPT Version :10

• Sequence 1: NP_001246965.1
• Gene: alpha-Est5 / 40905
• FlyBaseID: FBgn0261393
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_663578.1
• Gene: Ces2c / 234671
• MGIID: 2385905
• Length: 561
• Species: Mus musculus
• Alignment Length: 558
• Identity: 160/558 - (28%)
• Similarity: 244/558 - (43%)
• Gaps: 99/558 - (17%)

  Fly    18 GQIKGVKRLSLYDDP--YFSFEKIPFAKPPLGELRFRAPVPADPWSGVLD-------CTHYAEKP 73
            |||:| ..:.:.|..  ..:|..|||||||:|.|||..|...:|||||.|       |....:..
Mouse    41 GQIQG-SLIHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTAHPAMCLQNLDML 104

  Fly    74 TQRGL-----LTREIEGGEDCLYLNVYSKQLKSE-KPLPVMVYIYGGAFTVGEATRELYGPDYFM 132
            .:.||     :.......|||||||:|:.....| ..|||||:|:|||..:|.|:. ..|....:
Mouse   105 NEAGLPDMKMMLSSFPMSEDCLYLNIYTPAHAHEGSNLPVMVWIHGGALVIGMASM-FDGSLLTV 168

  Fly   133 TKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESA 197
            .:|:|:||:.||:..|||.|..|...:  ||.|..||..||:||:|.|::|.|:...:|:|||||
Mouse   169 NEDLVVVTIQYRLGVLGFFSTGDQHAR--GNWGYLDQAAALRWVQQNIAHFGGNPDRVTIFGESA 231

  Fly   198 GGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNP------AEDFAFRLAQQNGFTGENDDAKV 256
            ||.|....:.:..::||||.||..||.     |..|      :|..:..:|:.:|....:..| :
Mouse   232 GGTSVSSHVVSPMSQGLFHGAIMESGV-----ALLPDLISETSEMVSTTVAKLSGCEAMDSQA-L 290

  Fly   257 LEYLQGVPARDLVNHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVML 321
            :..|:|....:::..|          .:|...|.|  ..||  ..|:.|.|:......:..|.::
Mouse   291 VRCLRGKSEAEILAIN----------KVFKMIPAV--VDGE--FFPRHPKELLASEDFHPVPSII 341

  Fly   322 GGTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENLEYSQRLMKAYFGYSPPSSE 386
            |..:.|..:..|.|..:.:.:..::::..:.|..|  |........|.|..||:.|.|.:..:..
Mouse   342 GVNNDEFGWSIPVVMGSAQMIKGITRENLQAVLKD--TAVQMMLPPECSDLLMEEYMGDTEDAQT 404

  Fly   387 LLLNMLDFYSYKIF-------WHGFNRTFNARLTYAKAPTYYYRFDFDSPNFNFYRAKFCGDKIK 444
            |.:...:.....:|       .| |.|        :.||.|:|.|......|...|.    ..:|
Mouse   405 LQIQFTEMMGDFMFVIPALQVAH-FQR--------SHAPVYFYEFQHPPSYFKDVRP----PHVK 456

  Fly   445 TGVAHADDLSYLFRNAGSW--KLDKTSAEYRTIERMIGIWTAFAATSNPNC------PEIGH--- 498
            ..  |||::.::|.:. .|  |||.|..|.....||:..|..||...|||.      |.:.|
Mouse   457 AD--HADEIPFVFASF-FWGMKLDFTEEEELLSRRMMKYWANFARHGNPNSEGLPYWPVMDHDEQ 518

  Fly   499 ---LEWKPS-------------TKNDPKRV--INISSD 518
               |:.:|:             ||..|:::  :..|.|
Mouse   519 YLQLDIQPAVGRALKAGRLQFWTKTLPQKIQELKASQD 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	alpha/beta hydrolases	12..533	CDD:473884	160/558 (29%)
Ces2c	NP_663578.1	COesterase	32..540	CDD:395084	155/540 (29%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561