DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est5 and Ces2c

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_663578.1	Gene:	Ces2c / 234671	MGIID:	2385905	Length:	561	Species:	Mus musculus

Alignment Length:	558	Identity:	160/558 - (28%)
Similarity:	244/558 - (43%)	Gaps:	99/558 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GQIKGVKRLSLYDDP--YFSFEKIPFAKPPLGELRFRAPVPADPWSGVLD-------CTHYAEKP 73
            |||:| ..:.:.|..  ..:|..|||||||:|.|||..|...:|||||.|       |....:..
Mouse    41 GQIQG-SLIHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTAHPAMCLQNLDML 104

  Fly    74 TQRGL-----LTREIEGGEDCLYLNVYSKQLKSE-KPLPVMVYIYGGAFTVGEATRELYGPDYFM 132
            .:.||     :.......|||||||:|:.....| ..|||||:|:|||..:|.|:. ..|....:
Mouse   105 NEAGLPDMKMMLSSFPMSEDCLYLNIYTPAHAHEGSNLPVMVWIHGGALVIGMASM-FDGSLLTV 168

  Fly   133 TKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESA 197
            .:|:|:||:.||:..|||.|..|...:  ||.|..||..||:||:|.|::|.|:...:|:|||||
Mouse   169 NEDLVVVTIQYRLGVLGFFSTGDQHAR--GNWGYLDQAAALRWVQQNIAHFGGNPDRVTIFGESA 231

  Fly   198 GGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNP------AEDFAFRLAQQNGFTGENDDAKV 256
            ||.|....:.:..::||||.||..||.     |..|      :|..:..:|:.:|....:..| :
Mouse   232 GGTSVSSHVVSPMSQGLFHGAIMESGV-----ALLPDLISETSEMVSTTVAKLSGCEAMDSQA-L 290

  Fly   257 LEYLQGVPARDLVNHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVML 321
            :..|:|....:::..|          .:|...|.|  ..||  ..|:.|.|:......:..|.::
Mouse   291 VRCLRGKSEAEILAIN----------KVFKMIPAV--VDGE--FFPRHPKELLASEDFHPVPSII 341

  Fly   322 GGTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENLEYSQRLMKAYFGYSPPSSE 386
            |..:.|..:..|.|..:.:.:..::::..:.|..|  |........|.|..||:.|.|.:..:..
Mouse   342 GVNNDEFGWSIPVVMGSAQMIKGITRENLQAVLKD--TAVQMMLPPECSDLLMEEYMGDTEDAQT 404

  Fly   387 LLLNMLDFYSYKIF-------WHGFNRTFNARLTYAKAPTYYYRFDFDSPNFNFYRAKFCGDKIK 444
            |.:...:.....:|       .| |.|        :.||.|:|.|......|...|.    ..:|
Mouse   405 LQIQFTEMMGDFMFVIPALQVAH-FQR--------SHAPVYFYEFQHPPSYFKDVRP----PHVK 456

  Fly   445 TGVAHADDLSYLFRNAGSW--KLDKTSAEYRTIERMIGIWTAFAATSNPNC------PEIGH--- 498
            ..  |||::.::|.:. .|  |||.|..|.....||:..|..||...|||.      |.:.|
Mouse   457 AD--HADEIPFVFASF-FWGMKLDFTEEEELLSRRMMKYWANFARHGNPNSEGLPYWPVMDHDEQ 518

  Fly   499 ---LEWKPS-------------TKNDPKRV--INISSD 518
               |:.:|:             ||..|:::  :..|.|
Mouse   519 YLQLDIQPAVGRALKAGRLQFWTKTLPQKIQELKASQD 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	157/546 (29%)
Ces2c	NP_663578.1	COesterase	31..540	CDD:278561	155/540 (29%)
		Aes	<130..>233	CDD:223730	44/105 (42%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832721
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640