DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and NLGN1

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001352852.1	Gene:	NLGN1 / 22871	HGNCID:	14291	Length:	843	Species:	Homo sapiens

Alignment Length:	568	Identity:	160/568 - (28%)
Similarity:	243/568 - (42%)	Gaps:	143/568 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GQIKGVKRLSLYDD---PYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQR--- 76
            |:|:|:|: .|.::   |...|..:|:|.||.||.||:.|.|..|||.:.:.|.:|....|.
Human    60 GKIRGIKK-ELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIID 123

  Fly    77 GLLTREI-----------------EGGEDCLYLNVY---------SKQL---------------K 100
            |.|...:                 :..|||||||:|         .||.               .
Human   124 GRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRD 188

  Fly   101 SEKPLPVMVYIYGGAFTVGEATRELY-GPDYFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNA 164
            |..|.||||||:||::.  |.|..|| |.......:|:::|:|||:..|||||..|.:.|  ||.
Human   189 SGGPKPVMVYIHGGSYM--EGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAK--GNY 249

  Fly   165 GLKDQVLALKWVKQYISNFNGDDSNITVFGESAGGCSTHFMMC---------TEQTRGLFHKAIP 220
            ||.|.:.||:|..:.|..|.||...|||||..|||...:.:..         :..|:|||.:||.
Human   250 GLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIA 314

  Fly   221 MSGTVHNYWANN--PAEDFAFRLAQQNGFTGENDDAKVLEYLQGVPARDLVNHNLLTPEHRRNGL 283
            .|||..:.||.:  ||: :|..||.:.| ...:|..:::|.||..|.::||:.::....:.
Human   315 QSGTALSSWAVSFQPAK-YARMLATKVG-CNVSDTVELVECLQKKPYKELVDQDIQPARYH---- 373

  Fly   284 LFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVMLGGTSFEGLFMYPAVSANLKALDSL--S 346
             .||||.::   |:  |:|..|..:.......|:.:|||....||          ||.::::  |
Human   374 -IAFGPVID---GD--VIPDDPQILMEQGEFLNYDIMLGVNQGEG----------LKFVENIVDS 422

  Fly   347 QDPTRLVPVDVRTVSSEKENLEYSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFN-----R 406
            .|.......|. .||:..:||          :|| |...::|...:.| .|..:....|     :
Human   423 DDGISASDFDF-AVSNFVDNL----------YGY-PEGKDVLRETIKF-MYTDWADRHNPETRRK 474

  Fly   407 TFNARLTYAK----------------APTYYYRFDFDSPNFNFYRAKFCGDKIK--TGVAHADDL 453
            |..|..|..:                :|||:|.|        ::..:  .|::.  ...||.|::
Human   475 TLLALFTDHQWVAPAVATADLHSNFGSPTYFYAF--------YHHCQ--TDQVPAWADAAHGDEV 529

  Fly   454 SYL--FRNAGSWKL-----DKTSAEYRTIERMIGIWTAFAATSNPNCP 494
            .|:  ....|..:|     .|.......:  ::..||.||.|.:||.|
Human   530 PYVLGIPMIGPTELFPCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQP 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	160/568 (28%)
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	160/568 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142648
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740