DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and CES5A

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001177087.1	Gene:	CES5A / 221223	HGNCID:	26459	Length:	604	Species:	Homo sapiens

Alignment Length:	540	Identity:	155/540 - (28%)
Similarity:	231/540 - (42%)	Gaps:	108/540 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKES--SLETCELTLPVGQIKGVKRLSLYDD--PYFSFEKIPFAKPPLGELRFRAPVPADPWSGV 63
            ||:.  |.|..:....:|.|:| |::::...  |...|..:|||.||||.|||..|.||.||..:
Human    50 SKDEGPSAEGPQRNTRLGWIQG-KQVTVLGSPVPVNVFLGVPFAAPPLGSLRFTNPQPASPWDNL 113

  Fly    64 LDCTHYAEKPTQRG---LLTR--------EIEGGEDCLYLNVYS-KQLKSEKPLPVMVYIYGGAF 116
            .:.|.|.....|..   ||.:        :....|||||||:|: ....:...|||:|:..||||
Human   114 REATSYPNLCLQNSEWLLLDQHMLKVHYPKFGVSEDCLYLNIYAPAHADTGSKLPVLVWFPGGAF 178

  Fly   117 TVGEATRELY-GPDYFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYI 180
            ..|.|:  :: |......:||::|.:.||:...||.:..|.  ..|||...||||.||.||::.|
Human   179 KTGSAS--IFDGSALAAYEDVLVVVVQYRLGIFGFFTTWDQ--HAPGNWAFKDQVAALSWVQKNI 239

  Fly   181 SNFNGDDSNITVFGESAGGCSTHFMMCTEQTRGLFHKAIPMSGT-------VHNYWANNPAEDFA 238
            ..|.||.|::|:||||||..|...::.:...:|||||||..||.       .|:|   ..:||
Human   240 EFFGGDPSSVTIFGESAGAISVSSLILSPMAKGLFHKAIMESGVAIIPYLEAHDY---EKSED-- 299

  Fly   239 FRLAQQNGFTGEN--DDAKVLEYLQGVPARDLVNHNLLTPEHRR--NGLLFAFGPTVEAYVGEDC 299
              |.....|.|.|  |...:|..|:..|:::|:..:..|....|  :|..|
Human   300 --LQVVAHFCGNNASDSEALLRCLRTKPSKELLTLSQKTKSFTRVVDGAFF-------------- 348

  Fly   300 VVPKPPVEMARDAWSNNFPVMLGGTSFEGLFMYP------AVSANLKALD-SLSQDPTRLVPVDV 357
              |..|:::.........|.::|..:.|..|:.|      .:|.:.|:|. .|.|:...:.|..:
Human   349 --PNEPLDLLSQKAFKAIPSIIGVNNHECGFLLPMKEAPEILSGSNKSLALHLIQNILHIPPQYL 411

  Fly   358 RTVSSEKENLEYSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFNRTFNARLTY-----AKA 417
            ..|::|             ||......:|:..::||......|      ...|.:|.     |.|
Human   412 HLVANE-------------YFHDKHSLTEIRDSLLDLLGDVFF------VVPALITARYHRDAGA 457

  Fly   418 PTYYYRFDFDSPNFNFYRAKFCGDKIKTGVAHADDLSYLFRNA----------GSWKLDKTSAEY 472
            |.|:|.|......|...:..|    :|..  |||::.::|..|          |:     |..|.
Human   458 PVYFYEFRHRPQCFEDTKPAF----VKAD--HADEVRFVFGGAFLKGDIVMFEGA-----TEEEK 511

  Fly   473 RTIERMIGIWTAFAATSNPN 492
            ....:|:..|..||.|.|||
Human   512 LLSRKMMKYWATFARTGNPN 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	153/534 (29%)
CES5A	NP_001177087.1	COesterase	56..568	CDD:278561	153/534 (29%)
CES5A	NP_001177087.1	Aes	<155..>258	CDD:223730	42/106 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142606
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.690