DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est5 and Ces2e

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	158/529 - (29%)
Similarity:	231/529 - (43%)	Gaps:	100/529 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GQIKG----VKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQR-- 76
            ||::|    ||...   ....:|..|||||||:|.|||..|.|.:|||||.|.|.:.....|.
  Rat    39 GQVRGSFVHVKDTK---SGVHTFLGIPFAKPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNID 100

  Fly    77 GL--------LTRE-IEGGEDCLYLNVYS-KQLKSEKPLPVMVYIYGGAFTVGEATRELY-GPDY 130
            ||        ::|. :...||||||::|: .....:..|||||:|:||....|.|:  .| |...
  Rat   101 GLNLENLKIKMSRSPVSMSEDCLYLSIYTPAHTHKDSNLPVMVWIHGGGLCWGMAS--TYDGSML 163

  Fly   131 FMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGE 195
            ...:|||:||:.||:..|||.|..|...:  ||.|..|||.||:||:|.|.:|.|:...:|:|||
  Rat   164 AAIEDVVVVTIQYRLGILGFFSTGDEHAR--GNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGE 226

  Fly   196 SAGGCSTHFMMCTEQTRGLFHKAIPMSGT--VHNYWANNPAEDFAFRLAQQNGFTGENDDAKVLE 258
            ||||.|....:.:..::||||.||..||.  :.|. .:|.:|.....:|..:|....:.:| ::.
  Rat   227 SAGGISVSSHVVSPMSQGLFHGAIMESGVALLPNL-ISNTSEVIYTMVANLSGCEPVDSEA-LMS 289

  Fly   259 YLQGVPARDLVNHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVMLGG 323
            .|:.....:::..|.:.             .|:...| :...:|:.|:|:......:..|.::|.
  Rat   290 CLREKSEEEMLAINNIV-------------RTISGVV-DGKFLPRHPLELLASVDFHPVPSIIGI 340

  Fly   324 TSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENL--------EYSQRLMKAYFGY 380
            .|.|..::.|          .|..|.| :..::..|:.:..:|.        |.|..||:.|.|.
  Rat   341 NSDEYGWIIP----------MLHPDST-MKEINRETMRAVLKNTAVQMMLPPECSDLLMEEYMGD 394

  Fly   381 SPPSSELLLNMLDFYSYKIF-------WHGFNRTFNARLTYAKAPTYYYRFDFDSPNFNFYRAKF 438
            :..|..|.:...:.....||       .| |.|        :.||.|:|.|...|   ||.: ..
  Rat   395 TEDSKTLQIQFNEMMGDFIFVIPALQVAH-FQR--------SHAPVYFYEFQHQS---NFLK-DI 446

  Fly   439 CGDKIKTGVAHADDL----SYLFRNAGSW--KLDKTSAEYRTIERMIGIWTAFAATSNPNC---- 493
            ....:|..  |.|:|    .|||     |  |...|..|.....:||..|..||...|||.
  Rat   447 RPPHVKAD--HGDELPYVIGYLF-----WDMKFVFTEEEKLLSRKMIKYWANFARHGNPNSEGLP 504

  Fly   494 --PEIGHLE 500
              |.:.|.|
  Rat   505 YWPALDHDE 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	158/529 (30%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	158/529 (30%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	45/106 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640