DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and cest-28

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_504691.2	Gene:	cest-28 / 187305	WormBaseID:	WBGene00019654	Length:	548	Species:	Caenorhabditis elegans

Alignment Length:	559	Identity:	163/559 - (29%)
Similarity:	248/559 - (44%)	Gaps:	101/559 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MSKESSLETCELTLPVGQIKG-VKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLD 65
            :.:|...|  :|....|.|:| |.|:.  |.....:..||||||   .:||:.|.||..|..|.|
Worm     8 LEREKHSE--KLNATCGPIQGNVYRIG--DKTVDGYLGIPFAKP---LVRFKKPEPAGTWEEVRD 65

  Fly    66 CTHYAEKPTQRGLLTREIEGGED-------CLYLNVYSKQLKSE---KPLPVMVYIYGGAFTVGE 120
            ||.|..:..|.|.....|...:|       ||.|||:||...|:   |..||||||:||.:.. .
Worm    66 CTKYGPRCPQSGPFAEAINFQKDDIPDEANCLTLNVFSKISDSKNFNKTRPVMVYIHGGGYEC-S 129

  Fly   121 ATRELYGPDYFMT-----KDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYI 180
            |:|:..  ||.:.     ||||:|||||||..|||.:..|  ...|||..|.|..|.|.|::::|
Worm   130 ASRDYC--DYSVAGTLPLKDVVVVTLNYRVGILGFFTTGD--TVCPGNFALWDLTLGLNWIQKHI 190

  Fly   181 SNFNGDDSNITVFGESAGGCSTHFMMCTEQTRGLFHKAIPMS-GTVHNY---WANNPAEDFAFRL 241
            .:|.||..|||:||:|||......:..:..:|.||::.|.|| |.:..|   .||:.|: ..:..
Worm   191 ESFGGDPGNITIFGQSAGAACVDLLALSPHSRDLFNRVIVMSGGALCEYAVRTANSQAK-VCYEF 254

  Fly   242 AQQNGFTGENDDAKVLEYLQGVPARDLVNHNLLTPEHRRNGL------LFAFGPTVEAYVGEDCV 300
            |:..|:.|.|... :..:::..|..::         .:.||.      :.|:.|.:     :|..
Worm   255 ARHLGYDGTNSQT-LFNWMKSKPLEEI---------EKMNGFQVPASGILAWTPNL-----DDDF 304

  Fly   301 VPKPPVEMARDAWSNNFPVMLGGTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTV----- 360
            .||...|:...|...:  :|:|....||||           .:.|.:|||  .|::...:
Worm   305 FPKSLDELRIGAPKKD--IMMGFAEHEGLF-----------FEFLIKDPT--PPLEALKLYVNEY 354

  Fly   361 ----------SSEKENLEYSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHG-FNRTFNARLTY 414
                      ::..:.:|:..|.::     ..........::||....:|..| |:...|. |.:
Worm   355 YKKDTGDHFEATRNKIIEFYSRNVE-----DTDEKSTKERLIDFVGDALFTAGVFDNAKNC-LKH 413

  Fly   415 AKAPTYYYRFDFDSPNFNFYRAKFCGDKIKTGVA--HADDLSYLFRNAGSWKLDKTSAEYRTIER 477
            .. ..:.|.||:.:|:....:.:|     .|.||  |..||.|:...........|..|::.||:
Worm   414 GN-NVWLYIFDYCNPSGFGNQEEF-----MTFVAPTHCTDLRYVLGEGLYSDFQPTEEEHKMIEK 472

  Fly   478 MIGIWTAFAATSNPNCPEIGHLEWKPSTKNDPKRVINIS 516
            |..|::.||...|||  |.|..||:..|.::|:|...||
Worm   473 MTTIYSNFAKYGNPN--EHGSSEWEKFTLDNPRRHFQIS 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	158/546 (29%)
cest-28	NP_504691.2	COesterase	17..516	CDD:278561	161/548 (29%)
cest-28	NP_504691.2	Aes	<112..>222	CDD:223730	48/114 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.720