DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and cest-30

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_504407.1	Gene:	cest-30 / 181871	WormBaseID:	WBGene00015071	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	572	Identity:	158/572 - (27%)
Similarity:	246/572 - (43%)	Gaps:	97/572 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LTLPVGQIKGVKRLSLYD--------DPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHY 69
            |..|.|.|:|    ::|.        |.|..   |||||.|:|.|:|:.||.|:.|:...||..|
Worm    34 LNAPCGPIRG----NIYKHKNGTKIVDGYLG---IPFAKAPVGALKFKKPVAAEKWTEPRDCYEY 91

  Fly    70 AEKPTQRG---LLTREIEGG---EDCLYLNVYSKQLK-SEKP--LPVMVYIYGGAFTVGEATREL 125
            .....|.|   .||.:....   |:||.|||::.:.| :|.|  |||:||||||.:.:|..:
Worm    92 GPGCPQTGRFAALTAKSTAAFAEENCLTLNVFAPRWKLAEFPKGLPVLVYIYGGGYEIGFTS--- 153

  Fly   126 YGPDYFMT-----KDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNG 185
            |..||.:|     |||::||:|||:..||||::.|....  ||.||.||.|||:||:..|::|.|
Worm   154 YMDDYSLTGTLPLKDVIVVTMNYRLGPLGFLTIADGIAN--GNYGLWDQTLALQWVQDNIASFGG 216

  Fly   186 DDSNITVFGESAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNPAE---DFAFRLAQQNGF 247
            :..::|:.|.|||..||.|:..:..:..||.::|.||||....:|..|.:   ......||..|:
Worm   217 NPESVTLSGTSAGATSTDFLSLSPHSNQLFQRSISMSGTAFCNFAIRPKDVEVGVCKEFAQFQGY 281

  Fly   248 TGENDDAKVLEYLQGVPARDLVNHNLLTPEHRRNGLLFAFG--PTVEAYVGEDCVVPKPPVEMAR 310
            || .|...:.::...        .|:...:........|.|  |.:..:.|:  ..|||...:.|
Worm   282 TG-TDSQSLFDWYMA--------QNVSKFKEVAGFQSTAAGAVPFIPNFDGD--FFPKPFDILRR 335

  Fly   311 DAWSNNFPVMLGGTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENLEYSQRLMK 375
            :|...:..:.:......|:.::..:.||  |.::...........||....:     :..::|..
Worm   336 EAPKKDALITVVTMESVGMIIFNPLFAN--AYNNFEGFINETYGPDVTDYYA-----DVKKKLTG 393

  Fly   376 AYFGYSPPSSELLLN--MLDFYSYKIFWHGFNRTFNARLTYAKAPTYYYRFDFDSPNFNFYRAKF 438
            .|......|.:..:|  ::|:.|..:|..|   |.:|..:|.|.....|     ..:||::
Worm   394 FYLKDVNASDKATVNRRVVDYVSDSVFNSG---TLDAVKSYVKYGNKVY-----LGSFNYF---- 446

  Fly   439 CGDKIKTGV---------AHADDLSYLFRNAGSWKLDKTSAEYRTIERMIGIWTAFAATSNPNCP 494
             .|..|..|         :|:.|..|.|.:........|..|...::....:...|....:|| .
Worm   447 -NDATKDMVELMQPFKEASHSSDFKYYFGSGVMANFTPTDEEMEVMDMSGTLMANFVKYGDPN-G 509

  Fly   495 EIGHLEWKPSTKNDPKRVINISSDVTIIDLPEYE--------KLQIWDNLYK 538
            :.|...|||.|...|.....       ||.|..|        :|:|:|::.|
Worm   510 KSGTKPWKPYTILKPNMYYK-------IDYPTCEMSDNFQNGRLRIYDDINK 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	149/534 (28%)
cest-30	NP_504407.1	COesterase	31..539	CDD:278561	154/555 (28%)
cest-30	NP_504407.1	Aes	<122..>230	CDD:223730	49/112 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157273
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.650