DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and cest-3

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_510042.2	Gene:	cest-3 / 181385	WormBaseID:	WBGene00008451	Length:	588	Species:	Caenorhabditis elegans

Alignment Length:	565	Identity:	134/565 - (23%)
Similarity:	218/565 - (38%)	Gaps:	145/565 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQRGLLTRE---IEGGEDCLYLNVYSK 97
            |:.:||||||||:|||..|...:||..:.:.|.|:........:..:   ....||||||||::.
Worm    43 FKNVPFAKPPLGKLRFSLPEWTNPWKNIRNATEYSPSCFSNSSMRTDSNFFPMSEDCLYLNVFTN 107

  Fly    98 Q--LKSEKPLPVMVYIYGGAFTVGEATR--ELYGPDYFMTKDVVLVTLNYRVDCLGFLSLKDPSL 158
            :  ||| |....:||.:||...:..|.:  :.:..:.::.::||.:...||:...|.|.....:|
Worm   108 EYCLKS-KNCSTVVYYHGGGINMDSAVQFNDTFILERYVKENVVFIIPAYRLGIFGLLYFGSNNL 171

  Fly   159 KVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAG-------GCSTHFMMCTEQTRGLFH 216
             ||.|..:.|..|||:::.|.||||.|...:|.:.|.|||       |.|.|.    :....|.:
Worm   172 -VPQNLAIHDCELALRFIHQEISNFGGHKDDINLMGHSAGAHISLIFGFSRHI----DPDHKLIN 231

  Fly   217 KAIPMSGTVHNYWANNP------AEDFAFRL-AQQNGFTGENDDAKVLEYLQGVPARDLVNHNLL 274
            :.|.:| .|.:|  :.|      ..|||.|: ..:...|..  |.::::.|:...||.|::...|
Worm   232 RIIVLS-PVPSY--DMPELLIKNCYDFAERVGCYKRNVTAR--DTEIVKCLRKKDARGLMSMQRL 291

  Fly   275 TPEHR--------------RNGLLFAF-----------GPTVEAYVGEDCVVPKPPVEMARDAWS 314
            ....|              |:..:..|           |.||:....:......|.:..:...|.
Worm   292 MENDRLYFWNFLAGEPFMYRDESIADFKEYAVKRDMLIGNTVDEVKWKRLKKENPAIAGSFMDWE 356

  Fly   315 N--------NF-----PVMLGGTSF-EGLFMYPAVSANLKA-------LDSLSQDPTRLVPVDVR 358
            |        ||     ||.....|| :|:|:..|..|..:|       |...:|.|:..|.....
Worm   357 NPYEVAHKFNFYHDSAPVNSTYESFTQGIFVSTATYAEAQANAGGTVYLFQSNQQPSSHVSDMQY 421

  Fly   359 TVSSEKENLEYSQR-LMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFNRTFNARLTYAKAPTYYY 422
            .|.:.:|:...|.. :|..::      |::::|...|.|....|...            .|:
Worm   422 FVGTHREDYHTSDMDIMDTFY------SKMIVNFTKFGSPSPVWEPL------------VPS--- 465

  Fly   423 RFDFDSPNFNFYRAKFCGDKIKTGV-------AHADDLSYLFRNAGSWKLDKTSAEYRTIERMIG 480
                   ..|:|..:...:|   |:       .|..|:::       |.::.|:.: |.:.|.
Worm   466 -------RMNYYALEVNTEK---GIWPRMEEDFHESDVNF-------WFINMTAFD-REVTRQ-- 510

  Fly   481 IWTAFAATSNPNCPEIGHLEWKP--------STKNDPKRVINISS 517
                 ..|||..     .|.|.|        .||.:.....:|||
Worm   511 -----KKTSNGT-----SLTWSPMHPGPVILPTKTNESSSFDISS 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	131/556 (24%)
cest-3	NP_510042.2	Abhydrolase	23..496	CDD:304388	119/501 (24%)
cest-3	NP_510042.2	Aes	<118..>254	CDD:223730	39/143 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157130
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740