Protein Alignment alpha-Est5 and cest-2.3

DIOPT Version :9

• Sequence 1: NP_001246965.1
• Gene: alpha-Est5 / 40905
• FlyBaseID: FBgn0261393
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_506510.2
• Gene: cest-2.3 / 179918
• WormBaseID: WBGene00013873
• Length: 665
• Species: Caenorhabditis elegans
• Alignment Length: 603
• Identity: 147/603 - (24%)
• Similarity: 238/603 - (39%)
• Gaps: 151/603 - (25%)

  Fly     7 SLETCELTLPVGQIKGVKRLSLYDDPYFS-----FEKIPFAKPPLGELRFRAPVPADPWSGVLD- 65
            |:.| .:.|..|.|:| |.|:....|:.:     |..||:.:||:||||||.|.....|.|||:
 Worm    15 SIST-RIQLSTGTIEG-KILNATYSPFGNQTATVFLGIPYVEPPIGELRFRKPRLLKSWEGVLET 77

  Fly    66 ------CTHYAEKPTQRGLLTREIEGGEDCLYLNVYSKQ-LKSEKPLPVMVYIYGGAFTV--GEA 121
                  |..|..|..:.|.:.   |..|||||.||::.| ....|...||:.::||....  |.|
 Worm    78 KDYKPACMSYWRKTFKNGFVG---EISEDCLYANVFTNQYCLQNKNCSVMIVVHGGRLVCESGSA 139

  Fly   122 TRELYGPDYFMT------KDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYI 180
                :.|:.|:.      :::|:||.|||:...||......:...  |..:.|.:.|:|||::.|
 Worm   140 ----FKPEIFINNFVGQDRNIVVVTFNYRLGVFGFGVFNGETGDT--NVAMYDMLEAVKWVRKEI 198

  Fly   181 SNFNGDDSNITVFGESAG-GCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNPAEDFAFRLAQQ 244
            ..|.|:...||:.|.||| |....|...| .::||.|:.|.||.         |.:|.: :.|..
 Worm   199 DQFGGNKDRITMAGHSAGAGLIVDFTSST-LSKGLLHQQIVMSA---------PLQDIS-KSANF 252

  Fly   245 NGFT--GENDDAKVLEY----------------LQGVPARDLVNHNLLTPEHRRNGLLFAFGPTV 291
            .|.|  .:|......||                ||...|:||::..|   ..::|...:...|.|
 Worm   253 KGMTIVAQNVGCIPKEYGFRKLSKTQINKTYLCLQNKSAQDLLHAQL---SMQQNSTFYFGSPRV 314

  Fly   292 EAYVGEDCVVPKPPVEMARDAWSN--NFPVMLGGTSFEGLFMYPAVSANLKALDSL-SQDPTRLV 353
            :.    |.:...|         .|  ||..:....:|.|     ..:..|:  ||| ..||
 Worm   315 DG----DFITDYP---------DNLFNFNTIYPINTFIG-----TTTGELR--DSLYITDP---- 355

  Fly   354 PVDVRTVSSEKENLEYSQRLMK---AYFGY------------------SPPSSELLLNMLDFYSY 397
                       :|....::|:|   .:.||                  :...::.|.:.::|||
 Worm   356 -----------KNDRIKEQLLKNMCEHVGYELFEKPEEFTKKCGNYYKNGTDAQFLSDDMEFYS- 408

  Fly   398 KIFWHGFNRTFNARLTYAKAPTYYYRFDFDSPNFNFYRAKFCGDKIKTGVAHADDLSYLFRNAGS 462
                 |..:..||. ..|.:..:.|.:|:......|::....     ....|::||.|.|   |:
 Worm   409 -----GAIKVANAH-KRANSKVFMYSYDYKGAGTAFHKYLEA-----PSPHHSEDLIYTF---GT 459

  Fly   463 WKLDKTSAEYRTIERMI-GIWTAFAATSNPNCPEIGHLEWKPSTKNDPKR---VINISSDVTIID 523
            .:....:.:| .|||:. |:...|....:|:..:.  .:|:..|:.  ||   :|:...:.|:..
 Worm   460 SRGPFVAKDY-VIERIYSGMLANFINFEDPSPSKT--QQWRQYTQE--KREYFLIDFDKNFTMPG 519

  Fly   524 LPEY---EKLQIWDNLYK 538
            :.::   ..|..|....|
 Worm   520 MKDHYYTRALDFWSTAGK 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	140/567 (25%)
cest-2.3	NP_506510.2	Abhydrolase	20..532	CDD:389770	143/590 (24%)
		CemA	<550..>647	CDD:383495

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157042
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740