DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and cest-17

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_505114.1	Gene:	cest-17 / 179198	WormBaseID:	WBGene00019477	Length:	571	Species:	Caenorhabditis elegans

Alignment Length:	573	Identity:	153/573 - (26%)
Similarity:	235/573 - (41%)	Gaps:	100/573 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ELTLPVGQIKGVKRLS-LYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGV-LDCTHYAEK-- 72
            ::|.|.|.|.|.:..| :....|..|..|.:..||....||:.|.|.:.|..: .|.||:...
Worm    23 KVTTPYGPIVGFEHKSTVTGSKYHVFLGIRYGNPPDHIYRFQKPEPVEKWPHINHDATHFRASCI 87

  Fly    73 PTQRGLLTREIEGGEDCLYLNVYSKQLKSEKPLPVMVYIYGGAFTVGEATRELY--GPDYFMTKD 135
            |:.|..|..::...||||:||:.:.....||.|||:|:|:||.|..|:.:...|  ..|.|::||
Worm    88 PSLRSELEEQVNYSEDCLFLNIVTPPDAKEKKLPVLVFIHGGGFQFGDTSMIGYQKAADNFVSKD 152

  Fly   136 VVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGGC 200
            ::.|::.||:..|||.:..|.  ::|||.||.||.|||:::.:.:.:|.||...||:.|.|||..
Worm   153 IIFVSIQYRLGPLGFFTTGDS--EIPGNMGLWDQTLALQFLHEVLPDFGGDPDRITLAGHSAGAA 215

  Fly   201 STHFMMCTEQTRGLFHKAIPMSGTVHNYWANNPAEDFAFRLAQQNGFTGENDDAKVLEYLQGVP- 264
            |...::.:..:..||.:||.:||::               .::.|......||::.|....|.|
Worm   216 SVSALLYSPHSDHLFSQAIQLSGSI---------------FSESNLDRNVVDDSRKLAKAAGCPQ 265

  Fly   265 -----ARDLVN----HNLLTPEHRRNGLLFAFGPTVE---AYVGEDCVVPKPPVEMARDAWSNNF 317
                 .||.:.    ..||........||  .||..:   .|..:| ..|....:|:|.|....
Worm   266 EDSKELRDCIEIRTVDELLDAMESIGELL--PGPRTKKFHPYFDKD-FFPYDIEKMSRKAPKKR- 326

  Fly   318 PVMLGGTSFE-GL-FMYPAVSANL-----KALDSLSQDPTRLVPVDVRTVSSEKENLEYSQR--- 372
             .|.|..|.| || .:||...|.|     ::..:.|:|  .||......|:.|:|....|.|
Worm   327 -TMQGLVSLESGLSVLYPVKLAKLLGVPKESWSTYSKD--NLVDFIRSQVAVEQEFGTASARFSG 388

  Fly   373 LMKAYFGYSPPSS------ELLLNMLDFYSYKI---------FWHGFNRTFNARLTYAKAPTYYY 422
            |::.::...|.:.      ....|:|....|.|         ..||::             ||.|
Worm   389 LVEEFYLSGPMTGNSSFYLNAFANLLSDLQYNIPTLHEVELKLQHGWD-------------TYLY 440

  Fly   423 RFDFDSPNFNFYRAKFCGDKIKTGVAHADDLSYLFRNAGSWKL-----DKTSAEYRTIERMIGIW 482
            ..|:||..     .|.....|| |..||.:|.|||...|...:     ||....|        ..
Worm   441 IIDYDSET-----TKDPTHPIK-GPFHASELRYLFNFNGMDTIPFNDKDKKFENY--------FV 491

  Fly   483 TAFAATSNPNCPEIGHLEWKPSTKNDPKRVINISSDVTIIDLPEYEKLQIWDN 535
            .|.....|...|....|.|...:|:.|...:.::...::......|..::|.:
Worm   492 NAIVNFINTGTPSTKALLWPAVSKSQPFANLLLNDKPSVQTSFRQEAYELWQS 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	150/546 (27%)
cest-17	NP_505114.1	COesterase	20..542	CDD:278561	152/569 (27%)
cest-17	NP_505114.1	Aes	<109..>225	CDD:223730	43/117 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720