DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and cest-35.2

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_504398.1	Gene:	cest-35.2 / 178910	WormBaseID:	WBGene00016863	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	527	Identity:	165/527 - (31%)
Similarity:	243/527 - (46%)	Gaps:	82/527 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 IPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQRGLL--------TREIEGGEDCLYLNVY 95
            |||||.|:|:|||:..|.|:.|:..|||..|.....|...|        |......::||.|||:
Worm    42 IPFAKAPIGDLRFKKSVEAEKWTQPLDCYKYGPGCPQSAALGALMVSQATNHDFAEDNCLNLNVF 106

  Fly    96 SKQLKS-EKP--LPVMVYIYGGAFTVGEATRELYGPDYFMT-----KDVVLVTLNYRVDCLGFLS 152
            :.:.|| |.|  .|||||.|||.|.||.::   ...||.:|     |||:|||.|||:..|||.:
Worm   107 APKWKSAEFPNGFPVMVYFYGGGFEVGFSS---MFDDYSLTGTLPLKDVILVTPNYRIGPLGFFA 168

  Fly   153 LKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGGCSTHFMMCTEQTRGLFHK 217
            ..|...:  ||.||.||.|||:||:::|.:|.||.||:|:.|.||||.|..|:..:......|.|
Worm   169 TGDDVAR--GNWGLWDQALALQWVQKHIKSFGGDPSNVTISGTSAGGASVDFLSLSPHANKYFQK 231

  Fly   218 AIPMSGTVHNYWANNP-------AEDFAFR-LAQQNGFTGENDDAKVLEYLQGVPARDLVNHNLL 274
            .|||||.     |..|       .|...|| .|..:|:|| ||...:|::.|   ::|  :...|
Worm   232 FIPMSGA-----ATCPFGIRSKDVEGLIFREFANHHGYTG-NDSKSLLQWYQ---SQD--SEIFL 285

  Fly   275 TPEHRR---NGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVMLGGTSFEGLFMYPAVS 336
            ..|..:   :| :|:|.|..:   |:  ..|||..|:.::|......|.:|  .:|||......:
Worm   286 KAEGYKCPASG-MFSFVPNFD---GD--FFPKPFDELRKEAPKLGAIVSIG--EYEGLGFEDFYA 342

  Fly   337 ANLKALDSLSQDPTRLVPVDVRTVSSEKENLEYSQRLMKAYF--GYSPPSSELLLNMLDFYSYKI 399
            ........||   ..|.|..||    .:|  |..:|..::|.  |.:.....:...:::.:....
Worm   343 GQKTPQQMLS---AALGPEVVR----NRE--EVVKRAAESYLKNGGNENEENIAKTLVEIFGDYY 398

  Fly   400 FWHGFNRTFNARLTYAKAPTYYYRFDFDSPNFNFYRAKFCGDKIKTGVAHADDLSYLFRNAGSWK 464
            |..|...|..:.:.|... .|.|.|::.:||......|   ::......|..||.|:| ..|:.:
Worm   399 FSVGAFDTVRSLVKYGNT-VYLYSFNYFNPNTPIVFGK---NRPFNAANHGSDLRYIF-GEGTGE 458

  Fly   465 LDKTSAEYRTIERMIGIW-TAFAATSNPNCPEIGHLEWKPSTKNDPKRVINISSDVTIIDLPEYE 528
            ..|   |.|.:..|:|.: |.||...|||...:. :.|:..:.::|.|...|          :|.
Worm   459 FSK---EDRQVMDMMGTYHTNFAKYGNPNGKGVS-VPWEKYSLDNPGRYFKI----------DYP 509

  Fly   529 KLQIWDN 535
            |.::.||
Worm   510 KCEMADN 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	158/500 (32%)
cest-35.2	NP_504398.1	COesterase	14..515	CDD:278561	163/524 (31%)
cest-35.2	NP_504398.1	Aes	<105..>239	CDD:223730	64/143 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157290
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.650