DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est5 and cest-27

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_871861.2	Gene:	cest-27 / 171610	WormBaseID:	WBGene00018958	Length:	561	Species:	Caenorhabditis elegans

Alignment Length:	584	Identity:	169/584 - (28%)
Similarity:	263/584 - (45%)	Gaps:	120/584 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TCELTLPVGQIKGVKRLSLYDDPYFS----FEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYA 70
            ||      |.||||.    |:....|    |..||:|:||:|.|||:.||....|:..|||..:.
Worm    31 TC------GPIKGVG----YEQEDGSVVEGFLGIPYAEPPIGALRFKKPVAHRKWTEPLDCVRFG 85

  Fly    71 EKPTQRGLLTREI-----EGGEDCLYLNVYSKQLKS-EKP--LPVMVYIYGGAFTVGEATRELYG 127
            .:..|...|..:.     :..|.||.|||::.:.:| |.|  .||||:|:||.|.|..::.  ||
Worm    86 PRSPQNDELLGQFVNTVGKSEEHCLSLNVFTPKWESNEWPDGFPVMVFIHGGGFAVHSSSN--YG 148

  Fly   128 ----PDYFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDS 188
                .....|||||:||:|||:..|||.:..|...:  ||.||.||..||:||::.|.:|.||..
Worm   149 CASIARNLCTKDVVVVTINYRLGVLGFFTTGDEVCR--GNLGLWDQTAALEWVQENIQSFRGDPD 211

  Fly   189 NITVFGESAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNPAEDFAFRLAQQN-------- 245
            |:|:||:||||.|...:..:..:||||::||||:|        |...|||.|.::|.
Worm   212 NVTIFGQSAGGASVDLLCLSPHSRGLFNRAIPMAG--------NGECDFAMRTSEQQAQLSREFA 268

  Fly   246 ---GFTGENDDAKVLEYLQGVPARDLVNHNL-LTP----EHRRNGLLFAFGPTVEAYVGEDCVVP 302
               |:.|:::|::  :.||.:..:.|....: :.|    :|.:.|.|: |.|..:   |:  ..|
Worm   269 RYLGWEGDDNDSE--DLLQFIDQQPLYKIEMGINPKRGFKHSQAGSLY-FVPNFD---GD--FFP 325

  Fly   303 KPPVEMARDAWSNNFPVMLGGTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENL 367
            ||..::.::|  ....:|.|.|.:||||..        ||.:||::|..:              .
Worm   326 KPLNQLRKEA--PKMQIMTGTTKYEGLFFI--------ALGALSKNPEGI--------------K 366

  Fly   368 EYSQRLMKAYFGYSPPSSELLLNMLDFY---------------------SYKIFWHGFNRTFNAR 411
            ::..|:.|. ..|...:.::|..:.|||                     .|.|. :|..|..|.
Worm   367 KFMGRIFKE-CDYGERADDVLQMVYDFYFKGVHPKDHEKNMHQIVKFIGDYSIN-YGTYRLANI- 428

  Fly   412 LTYAKAPTYYYRFDF-DSPNFNFYR--AKFCGDKIKTGVAHADDLSYLFRNAGSWKLDKTSAEYR 473
            :|..:...|:|:||: :|..|..:|  ..|.|.      .|..::.|:.......|......:.:
Worm   429 MTDLQHDVYFYQFDYHNSAGFGVFRWLLPFLGS------THCTEMRYVLGKGIISKFRPNDNDKK 487

  Fly   474 TIERMIGIWTAFAATSNPNCPEIGHLEWKPSTKNDPKRVINIS-SDVTIIDLPEYEKLQIWDNL 536
            .:..|...:|.||...|||.......||:......|.|...|. .|..:::..:..:.::||.|
Worm   488 MLHVMTTYFTNFAKYGNPNGENQETGEWQKHDSAHPFRHFKIDLDDSEMVEDYQERRAELWDKL 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	162/555 (29%)
cest-27	NP_871861.2	COesterase	29..541	CDD:278561	166/572 (29%)
cest-27	NP_871861.2	Aes	<114..>283	CDD:223730	70/182 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157307
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.750