DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est5 and Ces3b

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_653094.2	Gene:	Ces3b / 13909	MGIID:	3644960	Length:	571	Species:	Mus musculus

Alignment Length:	550	Identity:	157/550 - (28%)
Similarity:	238/550 - (43%)	Gaps:	124/550 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ELTLPVGQIKGVKRLSLYDDPYF--SFEKIPFAKPPLGELRFRAPVPADPWSGVLD-------CT 67
            |:..|:|:::| :::.:.|....  .|..||||:.|:|.|||.||:|..||.||.|       |.
Mouse    38 EVDTPLGRVRG-RQVGVKDTDRMVNVFLGIPFAQAPVGPLRFSAPLPPQPWEGVRDASINPPMCL 101

  Fly    68 HYAEKP-TQRGLLTREIE---GGEDCLYLNVYS-KQLKSEKPLPVMVYIYGGAFTVGEATRE--- 124
            ...||. ..|..|..:|:   ..||||.||:|| .::.:....||||:|:||:..||.:|.:
Mouse   102 QDVEKMINSRFGLNEKIKIFPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSSTSQDGS 166

  Fly   125 ---LYGPDYFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGD 186
               .||       |||:||:.||:...||||..|..:  |||.|..|.|.||:||:..|:.|.||
Mouse   167 ALAAYG-------DVVVVTVQYRLGIFGFLSTGDKHM--PGNRGFLDVVAALRWVQGNIAPFGGD 222

  Fly   187 DSNITVFGESAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNY-------WANNPAEDFAFRLAQQ 244
            .:.:|:||.||||.....:..:..:.||||:||..||.|...       |..  |::||..:|
Mouse   223 PNCVTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSGIVTTIMMEDMKPWPE--AQNFANSVA-- 283

  Fly   245 NGFTGENDDAKVLEYLQGVPARDLV---NHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPV 306
               .|....|::::.|.....:||:   |.|:                   :|:..|...|:.|.
Mouse   284 ---CGSASPAELVQCLLQKEGKDLIKQKNVNI-------------------SYIVNDSFFPQRPE 326

  Fly   307 EMARDAWSNNFPVMLGGTSFE-GLFMYPAVSANLKALDSLSQD---------------PTRLVPV 355
            ::..|......|.:||.|:.| |..:..:::. |..|:.||::               |..::|
Mouse   327 KLLADQQFPTVPYLLGVTNHEFGWLLLKSLNI-LDKLEHLSREDLLEISRPFLAIMEVPPEIMP- 389

  Fly   356 DVRTVSSEKENLEYSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFNRTFNARLTYAKAPTY 420
               ||..|..:....|...:..|.........::..|:|..|              |..|..|.:
Mouse   390 ---TVIDEYLDNGSDQSATRYAFQELLGDISFIIPTLNFSKY--------------LRDAGCPVF 437

  Fly   421 YYRFDFDSPNFNFYRAKFCGDKIKTGVAHADDLSYLFRNAGSWKLDK---------TSAEYRTIE 476
            .|.|.....:|    |||....:|..  ||.:.|::|  .|.:..|:         |..|.:...
Mouse   438 LYEFQHTPSSF----AKFKPAWVKAD--HASENSFVF--GGPFLTDESSLLAFPEATEEEKQLSL 494

  Fly   477 RMIGIWTAFAATSNPN------CPEIGHLE 500
            .|:..|:.||.|.|||      .|::..||
Mouse   495 TMMAQWSQFARTGNPNGKGLPPWPQLNQLE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	156/549 (28%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	156/549 (28%)
		Aes	75..>245	CDD:223730	70/178 (39%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832492
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740