DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est5 and Ces1g

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_067431.2	Gene:	Ces1g / 12623	MGIID:	88378	Length:	565	Species:	Mus musculus

Alignment Length:	577	Identity:	166/577 - (28%)
Similarity:	247/577 - (42%)	Gaps:	110/577 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SLETCELTL------PV-----GQIKGVKRLSL--YDDPYFSFEKIPFAKPPLGELRFRAPVPAD 58
            ||..| |:|      ||     |::.| |.::|  :..|...|..:||||||||.|||..|.||:
Mouse    10 SLTAC-LSLGHPSLPPVVHTVHGKVLG-KYVTLEGFSQPVAVFLGVPFAKPPLGSLRFAPPEPAE 72

  Fly    59 PWSGVLDCTHYA----EKP-----------TQRGLLTREIEGGEDCLYLNVYS-KQLKSEKPLPV 107
            |||.|...|.|.    :.|           .||.::..:.  .|||||||:|: ..|.....|||
Mouse    73 PWSFVKHTTSYPPLCYQNPEAALRLAELFTNQRKIIPHKF--SEDCLYLNIYTPADLTQNSRLPV 135

  Fly   108 MVYIYGGAFTV-GEATRELYGPDYFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVL 171
            ||:|:||...: |.:|.:  |....:.::||:|.:.||:...||.|.:|...:  ||.|..|||.
Mouse   136 MVWIHGGGLVIDGASTYD--GVPLAVHENVVVVVIQYRLGIWGFFSTEDEHSR--GNWGHLDQVA 196

  Fly   172 ALKWVKQYISNFNGDDSNITVFGESAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHN-YWANNPAE 235
            ||.||:..|:||.|:..::|:|||||||.|...::.:...:.|||:||..|..:.| ......|.
Mouse   197 ALHWVQDNIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAIAQSSVIFNPCLFGRAAR 261

  Fly   236 DFAFRLAQQNGFTGENDDAKVLEYLQGVPARDLVNHNLLTPEHRRNGLLFAFGPTVEAY-----V 295
            ..|.::|...| ......|.::..|:.....:|:..:|    ..:.|.:...|...|:|     |
Mouse   262 PLAKKIAALAG-CKTTTSAAMVHCLRQKTEDELLEVSL----KMKFGTVDFLGDPRESYPFLPTV 321

  Fly   296 GEDCVVPKPPVEMARDAWSNNFPVMLGGTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTV 360
            .:..::||.|.|:..:...|..|.|:|....|..::.|..      ||.    |.....:|.:|.
Mouse   322 IDGVLLPKAPEEILAEKSFNTVPYMVGINKHEFGWIIPMF------LDF----PLSERKLDQKTA 376

  Fly   361 SS----EKENLEYSQRLMKA----YFGYSPPSSELLLNMLDFYSYKIFWHGFNRTFNARL-TYAK 416
            :|    ....|..|::|:.|    |.|.:...:.:....||.....:|  |......:|. ..|.
Mouse   377 ASILWQAYPILNISEKLIPAAIEKYLGGTEDPATMTDLFLDLIGDIMF--GVPSVIVSRSHRDAG 439

  Fly   417 APTYYYRFDFDSPNFNFYRAKFCGDKIKTGVA--HADDLSYLFRNAGSWKLDKTSAEYRTIERMI 479
            ||||.|.:.        ||..|..|.....:.  |||:|..:: .|...|...:..|....:.::
Mouse   440 APTYMYEYQ--------YRPSFVSDDRPQELLGDHADELFSVW-GAPFLKEGASEEEINLSKMVM 495

  Fly   480 GIWTAFAATSNPNCPEIGHLEWKPSTKNDPKRVINISSDVTIIDLPEYEK----LQI 532
            ..|..||...|||...:.|  |                       |||::    |||
Mouse   496 KFWANFARNGNPNGEGLPH--W-----------------------PEYDQKEGYLQI 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	160/549 (29%)
Ces1g	NP_067431.2	COesterase	24..545	CDD:278561	161/562 (29%)
Ces1g	NP_067431.2	Aes	<121..>239	CDD:223730	45/121 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832623
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650