DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est5 and Ces1d

DIOPT Version :9

Sequence 1:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_579829.3	Gene:	Ces1d / 113902	RGDID:	70896	Length:	565	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	170/566 - (30%)
Similarity:	233/566 - (41%)	Gaps:	124/566 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VGQIKGV---KRLSL--YDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQR 76
            |..:||.   |.::|  :..|...|..|||||||||.|||..|.||:||:.|.:.|.|....:|.
  Rat    26 VNTVKGKVLGKYVNLEGFAQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWNFVKNTTSYPPMCSQD 90

  Fly    77 G--------LLTREIEG-----GEDCLYLNVYS-KQLKSEKPLPVMVYIYGGAFTVGEATRELY- 126
            .        |.|...|.     .|||||||||: ..|.....|||||:|:||...||.|:  .|
  Rat    91 AVGGQVLSELFTNRKENIPLQFSEDCLYLNVYTPADLTKNSRLPVMVWIHGGGLVVGGAS--TYD 153

  Fly   127 GPDYFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNIT 191
            |......::||:||:.||:...||.|..|...:  ||.|..|||.||.||:..|:||.|:..::|
  Rat   154 GQVLSAHENVVVVTIQYRLGIWGFFSTGDEHSQ--GNWGHLDQVAALHWVQDNIANFGGNPGSVT 216

  Fly   192 VFGESAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNPAEDFAFRLAQQNGFTGENDDAKV 256
            :|||||||.|...::.:...:.|||:||..||.|               |......|.....|.:
  Rat   217 IFGESAGGFSVSALVLSPLAKNLFHRAISESGVV---------------LTSALITTDSKPIANL 266

  Fly   257 LEYLQGVPA----------RDLVNHNLLTPEHRRNGLLF---AFGPTVEAY-----VGEDCVVPK 303
            :..|.|...          |......||....:.|  ||   ..|...|:|     |.:..|:||
  Rat   267 IATLSGCKTTTSAVMVHCLRQKTEDELLETSLKLN--LFKLDLLGNPKESYPFLPTVIDGVVLPK 329

  Fly   304 PPVEMARDAWSNNFPVMLG------GTSFEGLFMYPAVSANL--KALDSL--SQDPTRLVPVDVR 358
            .|.|:..:...|..|.::|      |.....|..||.....|  |...||  ...||..:...:.
  Rat   330 TPEEILTEKSFNTVPYIVGINKQEFGWIIPTLMGYPLSEGKLDQKTAKSLLWKSYPTLKISEKMI 394

  Fly   359 TVSSEKENLEYSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFNRTFNARL-TYAKAPTYYY 422
            .|.:||            |||.:...::......|..:..:|  |......:|. ..|.|||:.|
  Rat   395 PVVAEK------------YFGGTDDPAKRKDLFQDLVADVMF--GVPSVMVSRSHRDAGAPTFMY 445

  Fly   423 RFDFDSPNF-NFYRAK-FCGDKIKTGVAHADDLSYLFRNAGS-WKLDKTSAEYRTIERMI-GIWT 483
            .|:: .|:| :..|.| ..||       |.|:|..:|   || :..|..|.|...:.:|: ..|.
  Rat   446 EFEY-RPSFVSAMRPKTVIGD-------HGDELFSVF---GSPFLKDGASEEETNLSKMVMKYWA 499

  Fly   484 AFAATSNPNCPEIGHLEWKPSTKNDPKRVINISSDVTIIDLPEYEK 529
            .||...:||...:.|  |                       |||::
  Rat   500 NFARNGSPNGGGLPH--W-----------------------PEYDQ 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	167/545 (31%)
Ces1d	NP_579829.3	COesterase	24..545	CDD:278561	170/566 (30%)
		Aes	<121..>239	CDD:223730	49/121 (40%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336161
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750